An anionic strategy for three- and four-component coupling reactions leading to ketone frameworks based on vinylogous conversion of dilithio ketone α,β-dianions

Shin Ya Yamato, Go Hei Yamamura, Mitsuo Komatsu, Masashi Arai, Takahide Fukuyama, Ilhyong Ryu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

(Chemical Equation Presented) Ketone α,δ-dianions are generated by vinylogous extension of ketone α,β-dianions with alkenes such as vinylarenes, vinylsilanes, and vinyl sulfides, which then undergo reactions at the δ and α positions with different electrophiles, creating ketone frameworks. This work represents a cascade-type anion method that achieved three- and four-carbon component assembly reactions leading to ketones.

Original languageEnglish
Pages (from-to)2489-2491
Number of pages3
JournalOrganic Letters
Volume7
Issue number12
DOIs
StatePublished - 9 Jun 2005

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