Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder

Shin Teng, Chia Feng Lu, Po Shan Wang, Cheng Ta Li, Pei Chi Tu, Chih I. Hung, Tung Ping Su, Yu Te Wu

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Bipolar disorder is characterized by internally affective fluctuations. The abnormality of inherently mental state can be assessed using resting-state fMRI data without producing task-induced biases. In this study, we hypothesized that the resting-state connectivity related to the frontal, striatal, and thalamic regions, which were associated with mood regulations and cognitive functions, can be altered for bipolar disorder. We used the Pearson's correlation coefficients to estimate functional connectivity followed by the hierarchical modular analysis to categorize the resting-state functional regions of interest (ROIs). The selected functional connectivities associated with the striatal-thalamic circuit and default mode network (DMN) were compared between bipolar patients and healthy controls. Significantly decreased connectivity in the striatalthalamic circuit and between the striatal regions and the middle and posterior cingulate cortex was observed in the bipolar patients. We also observed that the bipolar patients exhibited significantly increased connectivity between the thalamic regions and the parahippocampus. No significant changes of connectivity related to the frontal regions in the DMN were observed. The changed resting-state connectivity related to the striatal-thalamic circuit might be an inherent basis for the altered emotional and cognitive processing in the bipolar patients.

Original languageEnglish
Article numbere96422
JournalPLoS ONE
Issue number5
StatePublished - 2 May 2014


Dive into the research topics of 'Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder'. Together they form a unique fingerprint.

Cite this