Altered gray matter volume in the frontal pain modulation network in patients with cluster headache

Fu Chi Yang; Kun Hsien Chou; Jong Ling Fuh; Chu Chung Huang; Jiing Feng Lirng; Yung Yang Lin; Ching Po Lin; Shuu Jiun Wang

doi:10.1016/j.pain.2013.02.005

Altered gray matter volume in the frontal pain modulation network in patients with cluster headache

Fu Chi Yang, Kun Hsien Chou, Jong Ling Fuh, Chu Chung Huang, Jiing Feng Lirng, Yung Yang Lin, Ching Po Lin^*, Shuu Jiun Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Previous functional imaging studies in episodic cluster headache (CH) patients revealed altered brain metabolism concentrated on the central descending pain control system. However, it remains unclear whether changes in brain metabolism during the "in bout" period are due to structural changes and whether these structural changes vary between the "in bout" and "out of bout" periods. To quantify brain structural changes in CH patients, the regional gray matter volume (GMV) was compared among 49 episodic CH patients during the "in bout" period and 49 age- and sex-matched controls. Twelve patients were rescanned during the "out of bout" period to evaluate the changes, if any, between these 2 periods. Compared with healthy controls, CH patients showed significant "in bout" GMV reductions in the bilateral middle frontal, left superior, and medial frontal gyri. Compared to "out of bout" scans, the "in bout" scans revealed significant GMV increases in the left anterior cingulate, insula, and fusiform gyrus. Additionally, compared to healthy controls, the "out of bout" scans revealed a trend of GMV reduction in the left middle frontal gyrus. These affected regions primarily belong to frontal pain modulation areas, and thus these GMV changes may reflect insufficient pain-modulating capacity in the frontal areas of CH patients.

Original language	English
Pages (from-to)	801-807
Number of pages	7
Journal	Pain
Volume	154
Issue number	6
DOIs	https://doi.org/10.1016/j.pain.2013.02.005
State	Published - Jun 2013

Keywords

Cluster headache
Pain matrix
Pain modulation
Voxel-based morphometry

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10.1016/j.pain.2013.02.005

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@article{f35b3164835e46a6b2adf8fe29a81b18,

title = "Altered gray matter volume in the frontal pain modulation network in patients with cluster headache",

abstract = "Previous functional imaging studies in episodic cluster headache (CH) patients revealed altered brain metabolism concentrated on the central descending pain control system. However, it remains unclear whether changes in brain metabolism during the {"}in bout{"} period are due to structural changes and whether these structural changes vary between the {"}in bout{"} and {"}out of bout{"} periods. To quantify brain structural changes in CH patients, the regional gray matter volume (GMV) was compared among 49 episodic CH patients during the {"}in bout{"} period and 49 age- and sex-matched controls. Twelve patients were rescanned during the {"}out of bout{"} period to evaluate the changes, if any, between these 2 periods. Compared with healthy controls, CH patients showed significant {"}in bout{"} GMV reductions in the bilateral middle frontal, left superior, and medial frontal gyri. Compared to {"}out of bout{"} scans, the {"}in bout{"} scans revealed significant GMV increases in the left anterior cingulate, insula, and fusiform gyrus. Additionally, compared to healthy controls, the {"}out of bout{"} scans revealed a trend of GMV reduction in the left middle frontal gyrus. These affected regions primarily belong to frontal pain modulation areas, and thus these GMV changes may reflect insufficient pain-modulating capacity in the frontal areas of CH patients.",

keywords = "Cluster headache, Pain matrix, Pain modulation, Voxel-based morphometry",

author = "Yang, {Fu Chi} and Chou, {Kun Hsien} and Fuh, {Jong Ling} and Huang, {Chu Chung} and Lirng, {Jiing Feng} and Lin, {Yung Yang} and Lin, {Ching Po} and Wang, {Shuu Jiun}",

note = "Funding Information: This study was supported in part by grants from the Taiwan National Science Council (98-2314-B-010-019-MY2, NSC 100-2628-E-010-002-MY3, NSC 101-2321-B-010-026); Taipei Veterans General Hospital (VGHUST101-G7-1-1, V101C-106, V101E7-003, 102AC-D715); NSC support for the Centre for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan (NSC100-2911-I-008-001); Brain Research Center, National Yang-Ming University, Taiwan; Tri-Service General Hospital (TSGH-C101-159); and a grant from the Ministry of Education, Aim for the Top University Plan of Taiwan. The authors also acknowledge MRI support from the MRI Core Laboratory of National Yang-Ming University, Taiwan. ",

year = "2013",

month = jun,

doi = "10.1016/j.pain.2013.02.005",

language = "English",

volume = "154",

pages = "801--807",

journal = "Pain",

issn = "0304-3959",

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TY - JOUR

T1 - Altered gray matter volume in the frontal pain modulation network in patients with cluster headache

AU - Yang, Fu Chi

AU - Chou, Kun Hsien

AU - Fuh, Jong Ling

AU - Huang, Chu Chung

AU - Lirng, Jiing Feng

AU - Lin, Yung Yang

AU - Lin, Ching Po

AU - Wang, Shuu Jiun

N1 - Funding Information: This study was supported in part by grants from the Taiwan National Science Council (98-2314-B-010-019-MY2, NSC 100-2628-E-010-002-MY3, NSC 101-2321-B-010-026); Taipei Veterans General Hospital (VGHUST101-G7-1-1, V101C-106, V101E7-003, 102AC-D715); NSC support for the Centre for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan (NSC100-2911-I-008-001); Brain Research Center, National Yang-Ming University, Taiwan; Tri-Service General Hospital (TSGH-C101-159); and a grant from the Ministry of Education, Aim for the Top University Plan of Taiwan. The authors also acknowledge MRI support from the MRI Core Laboratory of National Yang-Ming University, Taiwan.

PY - 2013/6

Y1 - 2013/6

N2 - Previous functional imaging studies in episodic cluster headache (CH) patients revealed altered brain metabolism concentrated on the central descending pain control system. However, it remains unclear whether changes in brain metabolism during the "in bout" period are due to structural changes and whether these structural changes vary between the "in bout" and "out of bout" periods. To quantify brain structural changes in CH patients, the regional gray matter volume (GMV) was compared among 49 episodic CH patients during the "in bout" period and 49 age- and sex-matched controls. Twelve patients were rescanned during the "out of bout" period to evaluate the changes, if any, between these 2 periods. Compared with healthy controls, CH patients showed significant "in bout" GMV reductions in the bilateral middle frontal, left superior, and medial frontal gyri. Compared to "out of bout" scans, the "in bout" scans revealed significant GMV increases in the left anterior cingulate, insula, and fusiform gyrus. Additionally, compared to healthy controls, the "out of bout" scans revealed a trend of GMV reduction in the left middle frontal gyrus. These affected regions primarily belong to frontal pain modulation areas, and thus these GMV changes may reflect insufficient pain-modulating capacity in the frontal areas of CH patients.

AB - Previous functional imaging studies in episodic cluster headache (CH) patients revealed altered brain metabolism concentrated on the central descending pain control system. However, it remains unclear whether changes in brain metabolism during the "in bout" period are due to structural changes and whether these structural changes vary between the "in bout" and "out of bout" periods. To quantify brain structural changes in CH patients, the regional gray matter volume (GMV) was compared among 49 episodic CH patients during the "in bout" period and 49 age- and sex-matched controls. Twelve patients were rescanned during the "out of bout" period to evaluate the changes, if any, between these 2 periods. Compared with healthy controls, CH patients showed significant "in bout" GMV reductions in the bilateral middle frontal, left superior, and medial frontal gyri. Compared to "out of bout" scans, the "in bout" scans revealed significant GMV increases in the left anterior cingulate, insula, and fusiform gyrus. Additionally, compared to healthy controls, the "out of bout" scans revealed a trend of GMV reduction in the left middle frontal gyrus. These affected regions primarily belong to frontal pain modulation areas, and thus these GMV changes may reflect insufficient pain-modulating capacity in the frontal areas of CH patients.

KW - Cluster headache

KW - Pain matrix

KW - Pain modulation

KW - Voxel-based morphometry

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DO - 10.1016/j.pain.2013.02.005

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SN - 0304-3959

VL - 154

SP - 801

EP - 807

JO - Pain

JF - Pain

IS - 6

ER -

Altered gray matter volume in the frontal pain modulation network in patients with cluster headache

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Keywords

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