All-trans Retinoic Acid Increases Notch1 Transcript Expression in Acute Promyelocytic Leukemia

Jen Tsun Lin; Ming Shiuan Wu; Wei Shu Wang; Chueh Chuan Yen; Tzeon Jye Chiou; Jin Hwang Liu; Mu Hua Yang; Ta Chon Chao; Shu Chaou Chou; Po Min Chen

doi:10.1007/BF02849800

All-trans Retinoic Acid Increases Notch1 Transcript Expression in Acute Promyelocytic Leukemia

Jen Tsun Lin^*, Ming Shiuan Wu, Wei Shu Wang, Chueh Chuan Yen, Tzeon Jye Chiou, Jin Hwang Liu, Mu Hua Yang, Ta Chon Chao, Shu Chaou Chou, Po Min Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 μM for up to 96 hours. The increased transcript level of Notch1 was in concert with that of CD11b in NB4 cells, but not in HL-60 cells. The expression of Notch1 gene might be specific for APL cells. As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL.

Original language	English
Pages (from-to)	337-343
Number of pages	7
Journal	Advances in Therapy
Volume	20
Issue number	6
DOIs	https://doi.org/10.1007/BF02849800
State	Published - 2003

Keywords

Acute promyelocytic leukemia
Notch1 gene
Retinoid acid

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10.1007/BF02849800

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title = "All-trans Retinoic Acid Increases Notch1 Transcript Expression in Acute Promyelocytic Leukemia",

abstract = "The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 μM for up to 96 hours. The increased transcript level of Notch1 was in concert with that of CD11b in NB4 cells, but not in HL-60 cells. The expression of Notch1 gene might be specific for APL cells. As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL.",

keywords = "Acute promyelocytic leukemia, Notch1 gene, Retinoid acid",

author = "Lin, {Jen Tsun} and Wu, {Ming Shiuan} and Wang, {Wei Shu} and Yen, {Chueh Chuan} and Chiou, {Tzeon Jye} and Liu, {Jin Hwang} and Yang, {Mu Hua} and Chao, {Ta Chon} and Chou, {Shu Chaou} and Chen, {Po Min}",

year = "2003",

doi = "10.1007/BF02849800",

language = "English",

volume = "20",

pages = "337--343",

journal = "Advances in Therapy",

issn = "0741-238X",

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TY - JOUR

T1 - All-trans Retinoic Acid Increases Notch1 Transcript Expression in Acute Promyelocytic Leukemia

AU - Lin, Jen Tsun

AU - Wu, Ming Shiuan

AU - Wang, Wei Shu

AU - Yen, Chueh Chuan

AU - Chiou, Tzeon Jye

AU - Liu, Jin Hwang

AU - Yang, Mu Hua

AU - Chao, Ta Chon

AU - Chou, Shu Chaou

AU - Chen, Po Min

PY - 2003

Y1 - 2003

N2 - The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 μM for up to 96 hours. The increased transcript level of Notch1 was in concert with that of CD11b in NB4 cells, but not in HL-60 cells. The expression of Notch1 gene might be specific for APL cells. As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL.

AB - The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in acute promyelocytic leukemia cells (APL), NB4, and HL-60 lacking t(15;17) was studied. The cells were treated with ATRA 0.5 μM for up to 96 hours. The increased transcript level of Notch1 was in concert with that of CD11b in NB4 cells, but not in HL-60 cells. The expression of Notch1 gene might be specific for APL cells. As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL.

KW - Acute promyelocytic leukemia

KW - Notch1 gene

KW - Retinoid acid

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U2 - 10.1007/BF02849800

DO - 10.1007/BF02849800

M3 - Article

C2 - 15058751

AN - SCOPUS:12144288252

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VL - 20

SP - 337

EP - 343

JO - Advances in Therapy

JF - Advances in Therapy

IS - 6

ER -

All-trans Retinoic Acid Increases Notch1 Transcript Expression in Acute Promyelocytic Leukemia

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