Advanced brain age in community-dwelling population with combined physical and cognitive impairments

Chen Yuan Kuo, Pei Lin Lee, Li Ning Peng, Wei Ju Lee, Pei Ning Wang, Liang Kung Chen, Kun Hsien Chou, Chih Ping Chung*, Ching Po Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We investigated whether advanced brain biological age is associated with accelerated age-related physical and/or cognitive functional decline: mobility impairment no disability (MIND), cognitive impairment no dementia (CIND), and physio-cognitive decline syndrome (PCDS). We constructed a brain age prediction model using gray matter features from the magnetic resonance imaging of 1482 healthy individuals (aged 18–92 years). Predicted and chronological age differences were obtained (brain age gap [BAG]) and analyzed in another 1193 community-dwelling population aged ≥50 years. Among the 1193 participants, there were 501, 346, 148, and 198 in the robust, CIND, MIND, and PCDS groups, respectively. Participants with PCDS had significantly larger BAG (BAG = 2.99 ± 8.97) than the robust (BAG = −0.49 ± 9.27, p = 0.002; η2 = 0.014), CIND (BAG = 0.47 ± 9.16, p = 0.02; η2 = 0.01), and MIND (BAG = 0.36 ± 9.69, p = 0.036; η2 = 0.013) groups. Advanced brain aging is involved in the pathophysiology of the co-occurrence of physical and cognitive decline in the older people. The PCDS may be a clinical phenotype reflective of accelerated biological age in community-dwelling older individuals.

Original languageEnglish
Pages (from-to)114-123
Number of pages10
JournalNeurobiology of Aging
StatePublished - Oct 2023


  • Accelerated aging
  • Brain age
  • Cognitive frailty
  • Physio-cognitive decline syndrome


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