Acylated ghrelin and des-acyl ghrelin exert different effects on the gastrointestinal motility in conscious rats

Mineko Fujimiya; Akihiro Asakawa; Kazunori Fujino; Chih Yen Chen; Akio Inui

doi:10.1016/j.ics.2005.11.115

Acylated ghrelin and des-acyl ghrelin exert different effects on the gastrointestinal motility in conscious rats

Mineko Fujimiya^*, Akihiro Asakawa, Kazunori Fujino, Chih Yen Chen, Akio Inui

^*Corresponding author for this work

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Acylated ghrelin and des-acyl ghrelin exert opposite effects on the gastroduodenal motility, the former induces fasted motor activity in the duodenum but the latter disrupts the fasted motor activity in the antrum. Different brain mechanisms seem to be involved in these effects, NPY might be involved in the action of acylated ghrelin, while CRF type 2 receptor might be involved in the action of des-acyl ghrelin.

Original language	English
Pages (from-to)	361-367
Number of pages	7
Journal	International Congress Series
Volume	1287
DOIs	https://doi.org/10.1016/j.ics.2005.11.115
State	Published - Apr 2006

Keywords

Acylated ghrelin
CRF
Des-acyl ghrelin
Gastrointestinal motility
NPY
Rats

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10.1016/j.ics.2005.11.115

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title = "Acylated ghrelin and des-acyl ghrelin exert different effects on the gastrointestinal motility in conscious rats",

abstract = "Acylated ghrelin and des-acyl ghrelin exert opposite effects on the gastroduodenal motility, the former induces fasted motor activity in the duodenum but the latter disrupts the fasted motor activity in the antrum. Different brain mechanisms seem to be involved in these effects, NPY might be involved in the action of acylated ghrelin, while CRF type 2 receptor might be involved in the action of des-acyl ghrelin.",

keywords = "Acylated ghrelin, CRF, Des-acyl ghrelin, Gastrointestinal motility, NPY, Rats",

author = "Mineko Fujimiya and Akihiro Asakawa and Kazunori Fujino and Chen, {Chih Yen} and Akio Inui",

year = "2006",

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doi = "10.1016/j.ics.2005.11.115",

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AU - Fujimiya, Mineko

AU - Asakawa, Akihiro

AU - Fujino, Kazunori

AU - Chen, Chih Yen

AU - Inui, Akio

PY - 2006/4

Y1 - 2006/4

N2 - Acylated ghrelin and des-acyl ghrelin exert opposite effects on the gastroduodenal motility, the former induces fasted motor activity in the duodenum but the latter disrupts the fasted motor activity in the antrum. Different brain mechanisms seem to be involved in these effects, NPY might be involved in the action of acylated ghrelin, while CRF type 2 receptor might be involved in the action of des-acyl ghrelin.

AB - Acylated ghrelin and des-acyl ghrelin exert opposite effects on the gastroduodenal motility, the former induces fasted motor activity in the duodenum but the latter disrupts the fasted motor activity in the antrum. Different brain mechanisms seem to be involved in these effects, NPY might be involved in the action of acylated ghrelin, while CRF type 2 receptor might be involved in the action of des-acyl ghrelin.

KW - Acylated ghrelin

KW - CRF

KW - Des-acyl ghrelin

KW - Gastrointestinal motility

KW - NPY

KW - Rats

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U2 - 10.1016/j.ics.2005.11.115

DO - 10.1016/j.ics.2005.11.115

M3 - Article

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SN - 0531-5131

VL - 1287

SP - 361

EP - 367

JO - International Congress Series

JF - International Congress Series

ER -

Acylated ghrelin and des-acyl ghrelin exert different effects on the gastrointestinal motility in conscious rats

Abstract

Keywords

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