TY - JOUR
T1 - Acid-base controllable nanostructures and the fluorescence detection of H2PO4−by the molecular shuttling of tetraphenylethene-based [2]rotaxanes
AU - Arumugaperumal, Reguram
AU - Shellaiah, Muthaiah
AU - Lai, Yu Kuang
AU - Venkatesan, Parthiban
AU - Raghunath, Putikam
AU - Wu, Shu-Pao
AU - Lin, Ming-Chang
AU - Sun, Kien-Wen
AU - Chung, Wen Sheng
AU - Lin, Hong-Cheu
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2021.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/3/7
Y1 - 2021/3/7
N2 - Aggregation-induced emission (AIE)-active switchable [2]rotaxaneTR2with two different molecular stations and arm-terminated TPE units at both ends, and their derivatives were synthesized by means of threading, followed by the stoppering tacticviaclick chemistry. The AIE behavior of thread A1 and [2]rotaxanes (TR1,TR2, andTR3) in CH3CN were activated by tuning water fractions (fw), which induced the development of various well-defined nanostructures including spheres, nanorods, truncated cubes, and nanocubesviathe self-assembly of scaffolds. These AIE changes and distinct nanostructures formation verify that the reported analogous rotaxanes were controlled by the shuttling movements of the macrocycle along with wide ranges of multi-non-covalent interactions. The anion-templated construction of [2]rotaxaneTR2with a high level of structurally complex design always encounters more challenging tasks. Evidently, the key to the design involved encoding flexible arms on both triazolium motifs, and exhibited an impressive selectivity and sensitivity (with a detection limit of 0.20 μM) towards the complementary H2PO4−ion species. The specific mechanical molecular motion and host-guest interactions of mechanically interlocked molecules (MIMs) were also further explored by quantum mechanical calculations. Importantly, the AIE changes of [2]rotaxanesTR1,TR2, andTR3were further supported by their bioimaging applications and specifically, [2]rotaxaneTR2could be applied toin vitroimaging with H2PO4−at subcellular levels. This flexible multi-component synthetic strategy affords access to the systematic tuning of molecular structures and self-assembled architectures, and it will inspire further studies on the self-assembly of TPE-containing MIMs for materials science and biological applications.
AB - Aggregation-induced emission (AIE)-active switchable [2]rotaxaneTR2with two different molecular stations and arm-terminated TPE units at both ends, and their derivatives were synthesized by means of threading, followed by the stoppering tacticviaclick chemistry. The AIE behavior of thread A1 and [2]rotaxanes (TR1,TR2, andTR3) in CH3CN were activated by tuning water fractions (fw), which induced the development of various well-defined nanostructures including spheres, nanorods, truncated cubes, and nanocubesviathe self-assembly of scaffolds. These AIE changes and distinct nanostructures formation verify that the reported analogous rotaxanes were controlled by the shuttling movements of the macrocycle along with wide ranges of multi-non-covalent interactions. The anion-templated construction of [2]rotaxaneTR2with a high level of structurally complex design always encounters more challenging tasks. Evidently, the key to the design involved encoding flexible arms on both triazolium motifs, and exhibited an impressive selectivity and sensitivity (with a detection limit of 0.20 μM) towards the complementary H2PO4−ion species. The specific mechanical molecular motion and host-guest interactions of mechanically interlocked molecules (MIMs) were also further explored by quantum mechanical calculations. Importantly, the AIE changes of [2]rotaxanesTR1,TR2, andTR3were further supported by their bioimaging applications and specifically, [2]rotaxaneTR2could be applied toin vitroimaging with H2PO4−at subcellular levels. This flexible multi-component synthetic strategy affords access to the systematic tuning of molecular structures and self-assembled architectures, and it will inspire further studies on the self-assembly of TPE-containing MIMs for materials science and biological applications.
UR - http://www.scopus.com/inward/record.url?scp=85102385237&partnerID=8YFLogxK
U2 - 10.1039/d0tc05358a
DO - 10.1039/d0tc05358a
M3 - Article
AN - SCOPUS:85102385237
SN - 2050-7534
VL - 9
SP - 3215
EP - 3228
JO - Journal of Materials Chemistry C
JF - Journal of Materials Chemistry C
IS - 9
ER -