TY - JOUR
T1 - Abnormal Somatosensory Synchronization in Patients With Paroxysmal Kinesigenic Dyskinesia
T2 - A Magnetoencephalographic Study
AU - Hsiao, Fu Jung
AU - Hsu, Wan Yu
AU - Chen, Wei Ta
AU - Chen, Rou Shayn
AU - Lin, Yung Yang
N1 - Publisher Copyright:
© 2016 EEG and Clinical Neuroscience Society.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Paroxysmal kinesigenic dyskinesia (PKD) is a rare group of hyperkinetic movement disorders characterized by brief attacks of choreoathetosis or dystonia. To clarify the alterations of the functional connectivity within the somatosensory network in PKD patients, magnetoencephalographic (MEG) responses to paired median-nerve electrical stimulation were recorded in 10 PKD patients treated by carbamazepine or oxcarbamazepine and 22 age-matched controls. In patients, MEG recordings were obtained during drug-on and -off periods. Source-based functional connectivity analysis was performed between contralateral primary (cSI) and secondary (cSII), and ipsilateral secondary (iSII) somatosensory areas. During drug-off periods, patients with PKD demonstrated decreased cSI-iSII and increased cSII-iSII somatosensory connectivity at theta band. Drug-on periods lowered the functional connectivity in cSI-cSII at alpha and beta bands and in cSII-iSII at theta band compared with the drug-off periods. We suggest that altered theta functional connectivity in cSI-iSII and cSII-iSII could be the neurophysiological signatures in PKD.
AB - Paroxysmal kinesigenic dyskinesia (PKD) is a rare group of hyperkinetic movement disorders characterized by brief attacks of choreoathetosis or dystonia. To clarify the alterations of the functional connectivity within the somatosensory network in PKD patients, magnetoencephalographic (MEG) responses to paired median-nerve electrical stimulation were recorded in 10 PKD patients treated by carbamazepine or oxcarbamazepine and 22 age-matched controls. In patients, MEG recordings were obtained during drug-on and -off periods. Source-based functional connectivity analysis was performed between contralateral primary (cSI) and secondary (cSII), and ipsilateral secondary (iSII) somatosensory areas. During drug-off periods, patients with PKD demonstrated decreased cSI-iSII and increased cSII-iSII somatosensory connectivity at theta band. Drug-on periods lowered the functional connectivity in cSI-cSII at alpha and beta bands and in cSII-iSII at theta band compared with the drug-off periods. We suggest that altered theta functional connectivity in cSI-iSII and cSII-iSII could be the neurophysiological signatures in PKD.
KW - antiepileptic drugs (AEDs)
KW - functional connectivity
KW - magnetoencephalagraphy (MEG)
KW - paroxysmal kinesigenic dyskinesia (PKD)
KW - somatosensory evoked fields
UR - http://www.scopus.com/inward/record.url?scp=85020774935&partnerID=8YFLogxK
U2 - 10.1177/1550059416662575
DO - 10.1177/1550059416662575
M3 - Article
C2 - 27515699
AN - SCOPUS:85020774935
SN - 1550-0594
VL - 48
SP - 288
EP - 294
JO - Clinical EEG and Neuroscience
JF - Clinical EEG and Neuroscience
IS - 4
ER -