A Two-Electrode, Double-Pulsed Sensor Readout Circuit for Cardiac Troponin I Measurement

Siang Sin Shan; Shao Yung Lu; Yuan Po Yang; Shu Ping Lin; Patrick Carey; Minghan Xian; Fan Ren; Stephen Pearton; Chin Wei Chang; Jenshan Lin; Yu Te Liao

doi:10.1109/TBCAS.2020.3029912

A Two-Electrode, Double-Pulsed Sensor Readout Circuit for Cardiac Troponin I Measurement

Siang Sin Shan, Shao Yung Lu, Yuan Po Yang, Shu Ping Lin, Patrick Carey, Minghan Xian, Fan Ren, Stephen Pearton, Chin Wei Chang, Jenshan Lin, Yu Te Liao

Department of Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This paper presents a pulse-stimulus sensor readout circuit for use in cardiovascular disease examinations. The sensor is based on a gold nanoparticle plate with an antibody post-modification. The proposed system utilizes gated pulses to detect the biomarker Cardiac Troponin I in an ionic solution. The characteristic of the electrostatic double-layer capacitor generated by the analyte is related to the concentration of Cardiac Troponin I in the solvent. After sensing by the transistor, a current-to-frequency converter (I-to-F) and delay-line-based time-to-digital converter (TDC) convert the information into a series of digital codes for further analysis. The design is fabricated in a 0.18-μm standard CMOS process. The chip occupies an area of 0.92 mm2 and consumes 125 μW. In the measurements, the proposed circuit achieved a 1.77 Hz/pg-mL sensitivity and 72.43 dB dynamic range.

Original language	English
Pages (from-to)	1362-1370
Number of pages	9
Journal	IEEE Transactions on Biomedical Circuits and Systems
Volume	14
Issue number	6
DOIs	https://doi.org/10.1109/TBCAS.2020.3029912
State	Published - 1 Dec 2020

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title = "A Two-Electrode, Double-Pulsed Sensor Readout Circuit for Cardiac Troponin I Measurement",

abstract = "This paper presents a pulse-stimulus sensor readout circuit for use in cardiovascular disease examinations. The sensor is based on a gold nanoparticle plate with an antibody post-modification. The proposed system utilizes gated pulses to detect the biomarker Cardiac Troponin I in an ionic solution. The characteristic of the electrostatic double-layer capacitor generated by the analyte is related to the concentration of Cardiac Troponin I in the solvent. After sensing by the transistor, a current-to-frequency converter (I-to-F) and delay-line-based time-to-digital converter (TDC) convert the information into a series of digital codes for further analysis. The design is fabricated in a 0.18-μm standard CMOS process. The chip occupies an area of 0.92 mm2 and consumes 125 μW. In the measurements, the proposed circuit achieved a 1.77 Hz/pg-mL sensitivity and 72.43 dB dynamic range.",

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AU - Carey, Patrick

AU - Xian, Minghan

AU - Ren, Fan

AU - Pearton, Stephen

AU - Chang, Chin Wei

AU - Lin, Jenshan

AU - Liao, Yu Te

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

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N2 - This paper presents a pulse-stimulus sensor readout circuit for use in cardiovascular disease examinations. The sensor is based on a gold nanoparticle plate with an antibody post-modification. The proposed system utilizes gated pulses to detect the biomarker Cardiac Troponin I in an ionic solution. The characteristic of the electrostatic double-layer capacitor generated by the analyte is related to the concentration of Cardiac Troponin I in the solvent. After sensing by the transistor, a current-to-frequency converter (I-to-F) and delay-line-based time-to-digital converter (TDC) convert the information into a series of digital codes for further analysis. The design is fabricated in a 0.18-μm standard CMOS process. The chip occupies an area of 0.92 mm2 and consumes 125 μW. In the measurements, the proposed circuit achieved a 1.77 Hz/pg-mL sensitivity and 72.43 dB dynamic range.

AB - This paper presents a pulse-stimulus sensor readout circuit for use in cardiovascular disease examinations. The sensor is based on a gold nanoparticle plate with an antibody post-modification. The proposed system utilizes gated pulses to detect the biomarker Cardiac Troponin I in an ionic solution. The characteristic of the electrostatic double-layer capacitor generated by the analyte is related to the concentration of Cardiac Troponin I in the solvent. After sensing by the transistor, a current-to-frequency converter (I-to-F) and delay-line-based time-to-digital converter (TDC) convert the information into a series of digital codes for further analysis. The design is fabricated in a 0.18-μm standard CMOS process. The chip occupies an area of 0.92 mm2 and consumes 125 μW. In the measurements, the proposed circuit achieved a 1.77 Hz/pg-mL sensitivity and 72.43 dB dynamic range.

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A Two-Electrode, Double-Pulsed Sensor Readout Circuit for Cardiac Troponin I Measurement

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