A Traveling-Wave Dielectrophoresis Bio-Chip for Cell Manipulation in Standard CMOS Process

Yun Sheng Chan*, Ting Ting Hsu, Yi Po Chen, Hsu Min Wu, Yun Ming Wang, Chen Yi Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

This brief presents a lab-on-a-chip for cancer cell manipulation and separation. The programmable microelectrode dot array with 115,200 sub-microelectrodes is used to generate traveling wave electric field on the proposed chip. The proposed sub-microelectrode, 5× 5,μ m2 , is useful to improve the traveling field strength under low applied voltage. The proposed chip with area size of 3.2× 2.2 mm2 is implemented in standard 0.18 μ m CMOS process. Experimental results show that MDA-MB-231 cells and HELA cells can be manipulated at the speed of 1.08 μ m /s and 1.5 μ m /s respectively under the supply voltage of 1.8V.

Original languageEnglish
Pages (from-to)1582-1586
Number of pages5
JournalIEEE Transactions on Circuits and Systems I: Regular Papers
Volume69
Issue number3
DOIs
StatePublished - 1 Mar 2022

Keywords

  • Cell manipulation
  • Cell separation
  • Lab-on-a-chip
  • Programmable
  • twDEP

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