A Traveling-Wave Dielectrophoresis Bio-Chip for Cell Manipulation in Standard CMOS Process

Yun Sheng Chan; Ting Ting Hsu; Yi Po Chen; Hsu Min Wu; Yun Ming Wang; Chen Yi Lee

doi:10.1109/TCSII.2021.3102661

A Traveling-Wave Dielectrophoresis Bio-Chip for Cell Manipulation in Standard CMOS Process

Yun Sheng Chan^*, Ting Ting Hsu, Yi Po Chen, Hsu Min Wu, Yun Ming Wang, Chen Yi Lee

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

This brief presents a lab-on-a-chip for cancer cell manipulation and separation. The programmable microelectrode dot array with 115,200 sub-microelectrodes is used to generate traveling wave electric field on the proposed chip. The proposed sub-microelectrode, 5× 5,μ m2 , is useful to improve the traveling field strength under low applied voltage. The proposed chip with area size of 3.2× 2.2 mm2 is implemented in standard 0.18 μ m CMOS process. Experimental results show that MDA-MB-231 cells and HELA cells can be manipulated at the speed of 1.08 μ m /s and 1.5 μ m /s respectively under the supply voltage of 1.8V.

Original language	English
Pages (from-to)	1582-1586
Number of pages	5
Journal	IEEE Transactions on Circuits and Systems I: Regular Papers
Volume	69
Issue number	3
DOIs	https://doi.org/10.1109/TCSII.2021.3102661
State	Published - 1 Mar 2022

Keywords

Cell manipulation
Cell separation
Lab-on-a-chip
Programmable
twDEP

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TCSII.2021.3102661

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title = "A Traveling-Wave Dielectrophoresis Bio-Chip for Cell Manipulation in Standard CMOS Process",

abstract = "This brief presents a lab-on-a-chip for cancer cell manipulation and separation. The programmable microelectrode dot array with 115,200 sub-microelectrodes is used to generate traveling wave electric field on the proposed chip. The proposed sub-microelectrode, 5× 5,μ m2 , is useful to improve the traveling field strength under low applied voltage. The proposed chip with area size of 3.2× 2.2 mm2 is implemented in standard 0.18 μ m CMOS process. Experimental results show that MDA-MB-231 cells and HELA cells can be manipulated at the speed of 1.08 μ m /s and 1.5 μ m /s respectively under the supply voltage of 1.8V.",

keywords = "Cell manipulation, Cell separation, Lab-on-a-chip, Programmable, twDEP",

author = "Chan, {Yun Sheng} and Hsu, {Ting Ting} and Chen, {Yi Po} and Wu, {Hsu Min} and Wang, {Yun Ming} and Lee, {Chen Yi}",

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AU - Chan, Yun Sheng

AU - Hsu, Ting Ting

AU - Chen, Yi Po

AU - Wu, Hsu Min

AU - Wang, Yun Ming

AU - Lee, Chen Yi

PY - 2022/3/1

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N2 - This brief presents a lab-on-a-chip for cancer cell manipulation and separation. The programmable microelectrode dot array with 115,200 sub-microelectrodes is used to generate traveling wave electric field on the proposed chip. The proposed sub-microelectrode, 5× 5,μ m2 , is useful to improve the traveling field strength under low applied voltage. The proposed chip with area size of 3.2× 2.2 mm2 is implemented in standard 0.18 μ m CMOS process. Experimental results show that MDA-MB-231 cells and HELA cells can be manipulated at the speed of 1.08 μ m /s and 1.5 μ m /s respectively under the supply voltage of 1.8V.

AB - This brief presents a lab-on-a-chip for cancer cell manipulation and separation. The programmable microelectrode dot array with 115,200 sub-microelectrodes is used to generate traveling wave electric field on the proposed chip. The proposed sub-microelectrode, 5× 5,μ m2 , is useful to improve the traveling field strength under low applied voltage. The proposed chip with area size of 3.2× 2.2 mm2 is implemented in standard 0.18 μ m CMOS process. Experimental results show that MDA-MB-231 cells and HELA cells can be manipulated at the speed of 1.08 μ m /s and 1.5 μ m /s respectively under the supply voltage of 1.8V.

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KW - Cell separation

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JF - IEEE Transactions on Circuits and Systems I: Regular Papers

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A Traveling-Wave Dielectrophoresis Bio-Chip for Cell Manipulation in Standard CMOS Process

Abstract

Keywords

UN SDGs

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