A Single Flavoenzyme Forges the Pentacyclic Skeleton of α-Cyclopiazonic Acid

Keyphrases

• Pentacyclic 100%
• Flavoenzyme 100%
• Cyclopiazonic Acid 100%
• Indole Alkaloids 50%
• Binding Residues 50%
• Structural Characterization 50%
• X-ray Crystallography 50%
• Mutagenesis 50%
• Oxidative Cyclization 50%
• Stereospecific 50%
• Hydride Abstraction 50%
• Domain-specific Architecture 50%
• D-ring 50%
• Mechanistic Characterization 50%
• C-ring 50%
• Chemoenzymatic Synthesis 50%
• Amine Oxidase 50%
• Flavin-dependent 50%
• Three-Domain 50%
• Bicyclization 50%
• Mutational Dynamics 50%
• Structural Dynamic Analysis 50%
• Molecular Dynamics Analysis 50%
• High-resolution Structure 50%
• Enzyme Pathway 50%
• Substrate Access 50%
• Substrate-binding Domain 50%

Biochemistry, Genetics and Molecular Biology

• Flavoprotein 100%
• Active Site 50%
• Enzyme 50%
• DNA Template 50%
• Mutagenesis 50%
• Anabolism 50%
• Binding Domain 50%
• X-Ray Crystallography 50%
• Monoamine Oxidase 50%
• Amine Oxidase 50%
• Flavin 50%
• Alkaloid 50%