A randomized, double-blind comparison of cerivastatin and lovastatin for treatment of primary hypercholesterolemia

Wen Chung Yu, Chen Huan Chen*, Husan Ming Tsao, Yu An Ding

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background. The efficacy and safety of the new statin, cerivastatin, in the Chinese patients with primary hypercholesterolemia remains to be determined. Methods. In this prospective, double-blind, parallel-group study, patients with primary hypercholesterolemia were randomized to treatment with cerivastatin, 0.3 mg (n=21) or lovastatin, 20 mg (n = 22), for 8 weeks. The primary efficacy variable was percentage change of low-density lipoprotein (LDL) cholesterol from baseline. The secondary efficacy variables were percentage change of total cholesterol, triglycerides and high-density lipoprotein (HDL) cholesterol. Results. Both cerivastatin and lovastatin effectively reduced LDL cholesterol (-33.2% vs. -29.3%, p = 0.63), total cholesterol (-25% vs. -20%, p = 0.10), and triglycerides (-21% vs. -14%, p = 0.27) (all p < 0.0001 for comparison with baseline), and slight increased HDL cholesterol (+2% vs. +8%, p = 0.008) over the 8-week treatment period. The LDL cholesterol responsive rates according to the recommendations from the National Cholesterol Educational Panel (NCEP) were 43% and 32% for cerivastatin and lovastatin, respectively. The adverse event profiles of cerivastatin and lovastatin were similar. Conclusions. Cerivastatin 0.3 mg once daily is as effective and safe as lovastatin 20 mg once daily in lowering LDL and total cholesterol in Chinese patients with primary hypercholesterolemia.

Original languageEnglish
Pages (from-to)260-267
Number of pages8
JournalChinese Medical Journal (Taipei)
Volume65
Issue number6
StatePublished - Jun 2002

Keywords

  • HMG-CoA reductase inhibitors
  • Hypercholesterolemia
  • Statins

Fingerprint

Dive into the research topics of 'A randomized, double-blind comparison of cerivastatin and lovastatin for treatment of primary hypercholesterolemia'. Together they form a unique fingerprint.

Cite this