A programmable implantable microstimulator soc with wireless telemetry: Application in closed-loop endocardial stimulation for cardiac pacemaker

Shuenn Yuh Lee; Mario Yucheng Su; Ming Chun Liang; You Yin Chen; Cheng Han Hsieh; Chung Min Yang; Hsin Yi Lai; Jou Wei Lin; Qiang Fang

doi:10.1109/TBCAS.2011.2177661

A programmable implantable microstimulator soc with wireless telemetry: Application in closed-loop endocardial stimulation for cardiac pacemaker

Shuenn Yuh Lee^*, Mario Yucheng Su, Ming Chun Liang, You Yin Chen, Cheng Han Hsieh, Chung Min Yang, Hsin Yi Lai, Jou Wei Lin, Qiang Fang

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

A low-power, wireless, and implantable microstimulator system on chip with smart powering management, immediate neural signal acquisition, and wireless rechargeable system is proposed. A system controller with parity checking handles the adjustable stimulus parameters for the stimulated objective. In the current paper, the rat's intra-cardiac electrogram is employed as the stimulated model in the animal study, and it is sensed by a low-voltage and low-power monitoring analog front end. The power management unit, which includes a rectifier, battery charging and detection, and a regulator, is used for the power control of the internal circuits. The stimulation data and required clock are extracted by a phase-locked-loop-based phase shift keying demodulator from an inductive AC signal. The full chip, which consumes 48 $\mu {\rm W}$ only, is fabricated in a TSMC 0.35 $ \mu {\rm m}$ 2P4M standard CMOS process to perform the monitoring and pacing functions with inductively powered communication in the in vivo study.

Original language	English
Article number	6101569
Pages (from-to)	511-522
Number of pages	12
Journal	IEEE Transactions on Biomedical Circuits and Systems
Volume	5
Issue number	6
DOIs	https://doi.org/10.1109/TBCAS.2011.2177661
State	Published - Dec 2011

Keywords

Endocardial stimulation
Pacemaker
Power management
Programmable implantable stimulator
Wireless telemetry

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10.1109/TBCAS.2011.2177661

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Lee, S. Y., Su, M. Y., Liang, M. C., Chen, Y. Y., Hsieh, C. H., Yang, C. M., Lai, H. Y., Lin, J. W., & Fang, Q. (2011). A programmable implantable microstimulator soc with wireless telemetry: Application in closed-loop endocardial stimulation for cardiac pacemaker. IEEE Transactions on Biomedical Circuits and Systems, 5(6), 511-522. Article 6101569. https://doi.org/10.1109/TBCAS.2011.2177661

@article{49aafc3137694ec0a6ea9f5e77333be6,

title = "A programmable implantable microstimulator soc with wireless telemetry: Application in closed-loop endocardial stimulation for cardiac pacemaker",

abstract = "A low-power, wireless, and implantable microstimulator system on chip with smart powering management, immediate neural signal acquisition, and wireless rechargeable system is proposed. A system controller with parity checking handles the adjustable stimulus parameters for the stimulated objective. In the current paper, the rat's intra-cardiac electrogram is employed as the stimulated model in the animal study, and it is sensed by a low-voltage and low-power monitoring analog front end. The power management unit, which includes a rectifier, battery charging and detection, and a regulator, is used for the power control of the internal circuits. The stimulation data and required clock are extracted by a phase-locked-loop-based phase shift keying demodulator from an inductive AC signal. The full chip, which consumes 48 $\mu {\rm W}$ only, is fabricated in a TSMC 0.35 $ \mu {\rm m}$ 2P4M standard CMOS process to perform the monitoring and pacing functions with inductively powered communication in the in vivo study.",

keywords = "Endocardial stimulation, Pacemaker, Power management, Programmable implantable stimulator, Wireless telemetry",

author = "Lee, {Shuenn Yuh} and Su, {Mario Yucheng} and Liang, {Ming Chun} and Chen, {You Yin} and Hsieh, {Cheng Han} and Yang, {Chung Min} and Lai, {Hsin Yi} and Lin, {Jou Wei} and Qiang Fang",

note = "Funding Information: Manuscript received May 19, 2011; revised September 02, 2011; accepted November 16, 2011. Date of publication December 12, 2011; date of current version December 29, 2011. This work was supported by the Chip Implementation Center (CIC), the National Science Council, Taiwan, under Grant 100-EC-17-A-01-S1-040, NSC100–2220–E–194–002, NSC100–2220–E–194–003, NSC100-2628-E-194-003, and the Australian Research Council, Australia. This paper was recommended by Associate Editor D. Ham.",

year = "2011",

month = dec,

doi = "10.1109/TBCAS.2011.2177661",

language = "English",

volume = "5",

pages = "511--522",

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issn = "1932-4545",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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Lee, SY, Su, MY, Liang, MC, Chen, YY, Hsieh, CH, Yang, CM, Lai, HY, Lin, JW & Fang, Q 2011, 'A programmable implantable microstimulator soc with wireless telemetry: Application in closed-loop endocardial stimulation for cardiac pacemaker', IEEE Transactions on Biomedical Circuits and Systems, vol. 5, no. 6, 6101569, pp. 511-522. https://doi.org/10.1109/TBCAS.2011.2177661

A programmable implantable microstimulator soc with wireless telemetry: Application in closed-loop endocardial stimulation for cardiac pacemaker. / Lee, Shuenn Yuh; Su, Mario Yucheng; Liang, Ming Chun et al.
In: IEEE Transactions on Biomedical Circuits and Systems, Vol. 5, No. 6, 6101569, 12.2011, p. 511-522.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A programmable implantable microstimulator soc with wireless telemetry

T2 - Application in closed-loop endocardial stimulation for cardiac pacemaker

AU - Lee, Shuenn Yuh

AU - Su, Mario Yucheng

AU - Liang, Ming Chun

AU - Chen, You Yin

AU - Hsieh, Cheng Han

AU - Yang, Chung Min

AU - Lai, Hsin Yi

AU - Lin, Jou Wei

AU - Fang, Qiang

N1 - Funding Information: Manuscript received May 19, 2011; revised September 02, 2011; accepted November 16, 2011. Date of publication December 12, 2011; date of current version December 29, 2011. This work was supported by the Chip Implementation Center (CIC), the National Science Council, Taiwan, under Grant 100-EC-17-A-01-S1-040, NSC100–2220–E–194–002, NSC100–2220–E–194–003, NSC100-2628-E-194-003, and the Australian Research Council, Australia. This paper was recommended by Associate Editor D. Ham.

PY - 2011/12

Y1 - 2011/12

N2 - A low-power, wireless, and implantable microstimulator system on chip with smart powering management, immediate neural signal acquisition, and wireless rechargeable system is proposed. A system controller with parity checking handles the adjustable stimulus parameters for the stimulated objective. In the current paper, the rat's intra-cardiac electrogram is employed as the stimulated model in the animal study, and it is sensed by a low-voltage and low-power monitoring analog front end. The power management unit, which includes a rectifier, battery charging and detection, and a regulator, is used for the power control of the internal circuits. The stimulation data and required clock are extracted by a phase-locked-loop-based phase shift keying demodulator from an inductive AC signal. The full chip, which consumes 48 $\mu {\rm W}$ only, is fabricated in a TSMC 0.35 $ \mu {\rm m}$ 2P4M standard CMOS process to perform the monitoring and pacing functions with inductively powered communication in the in vivo study.

AB - A low-power, wireless, and implantable microstimulator system on chip with smart powering management, immediate neural signal acquisition, and wireless rechargeable system is proposed. A system controller with parity checking handles the adjustable stimulus parameters for the stimulated objective. In the current paper, the rat's intra-cardiac electrogram is employed as the stimulated model in the animal study, and it is sensed by a low-voltage and low-power monitoring analog front end. The power management unit, which includes a rectifier, battery charging and detection, and a regulator, is used for the power control of the internal circuits. The stimulation data and required clock are extracted by a phase-locked-loop-based phase shift keying demodulator from an inductive AC signal. The full chip, which consumes 48 $\mu {\rm W}$ only, is fabricated in a TSMC 0.35 $ \mu {\rm m}$ 2P4M standard CMOS process to perform the monitoring and pacing functions with inductively powered communication in the in vivo study.

KW - Endocardial stimulation

KW - Pacemaker

KW - Power management

KW - Programmable implantable stimulator

KW - Wireless telemetry

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U2 - 10.1109/TBCAS.2011.2177661

DO - 10.1109/TBCAS.2011.2177661

M3 - Article

AN - SCOPUS:84855343326

SN - 1932-4545

VL - 5

SP - 511

EP - 522

JO - IEEE Transactions on Biomedical Circuits and Systems

JF - IEEE Transactions on Biomedical Circuits and Systems

IS - 6

M1 - 6101569

ER -

A programmable implantable microstimulator soc with wireless telemetry: Application in closed-loop endocardial stimulation for cardiac pacemaker

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