A Programmable Bio-Chip with Adaptive Pattern-Control Micro-Electrode-Dot-Array

Yun Sheng Chan, Chen Yi Lee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A digital lab-on-CMOS chip is presented for nucleic acid amplification test. This biochip consists of programmable microelectrode dot array and digital timing controller. With novel circuit design in each microelectrode, microfluidic operations with velocity of 0.6mm/s, temperature profile with maximum change rate of 4.5℃/s and location sensing in μsecond-level can be achieved. As a result, test samples can be located first, followed by target operations to meet the requirements of specific medical tests with less reagent consumption and test time/cost. Furthermore bio-protocols can be derived to ensure both replicability and reliability in various medical tests. Preliminary results in loop-mediated isothermal amplification (LAMP) and PCR thermal cycle tests demonstrate the feasibility of our proposal with less test time of <40 min and <1 min respectively, making our proposal very suitable for mobile healthcare applications.

Original languageEnglish
Pages (from-to)1
Number of pages1
JournalIEEE Transactions on Circuits and Systems I: Regular Papers
DOIs
StateAccepted/In press - 2022

Keywords

  • bio-protocol
  • CMOS technology
  • digital microfluidics biochip (DMFB)
  • electrowetting-on-dielectric (EWOD)
  • Heating systems
  • microelectrode dot array (MEDA)
  • Microelectrodes
  • Microfluidics
  • programmable biochip
  • Sensors
  • Temperature measurement
  • Temperature sensors

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