A novel nanomolar highly selective fluorescent probe for imaging mercury (II) in living cells and zebrafish

Yen Yu Liu, Sanay Naha, Natesan Thirumalaivasan, Sivan Velmathi*, Shu-Pao Wu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A novel fluorescent probe, PES, which contains a bisethylsulfane moiety, displayed high specificity for Hg2+ detection. With Hg2+, PES showed significant blue fluorescence enhancement, while the metal ions Al3+, Ag+, Cr3+, Ca2+, Cu2+, Co2+, Cd2+, Fe3+, Fe2+, Mn2+, Mg2+, Ni2+, Zn2+, and Pb2+ exhibited only negligible fluorescence change. PES has been found to be an effective quantitative detector (LOD, 57 nM) for Hg2+ in semi-aqueous medium based on the Hg2+-induced removal of bisethylsulfane. It resulted in a turn-on blue fluorescence response. The fluorescence enhancement induced by Hg2+ was observed over the pH range of 4–10. Our fluorescence cell-imaging experiments revealed the applicability of the new probe, PES, to be a reliable and effective fluorescent marker for Hg2+ in living cells.

Original languageEnglish
Pages (from-to)673-678
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume277
DOIs
StatePublished - 20 Dec 2018

Keywords

  • Bioimaging
  • Hg
  • Pyrene
  • Zebrafish

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