A novel anabolic agent: A simvastatin analogue without HMG-CoA reductase inhibitory activity

Kuang Chan Hsieh, Chai Lin Kao, Chien Wei Feng, Zhi Hong Wen, Hsin Fang Chang, Shu Chun Chuang, Gwo Jaw Wang, Mei Ling Ho, Shou Mei Wu*, Je Ken Chang, Hui Ting Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

For the first time, structural information regarding the role of simvastatin in bone anabolism is described, and a bone-specific statin is introduced. Polyaspartate-conjugated simvastatin was synthesized by solid-phase synthesis with the assistance of microwave irradiation. It displays significant bone targeting and bone formation with less toxicity than simvastatin.

Original languageEnglish
Pages (from-to)4376-4379
Number of pages4
JournalOrganic Letters
Volume16
Issue number17
DOIs
StatePublished - 5 Sep 2014

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