Abstract
A new homoisoflavonoid, (R)-3-(2,4-dihydroxybenzyl)-5,7-dihydroxy-8-methoxychroman-4-one (1), has been isolated from the rhizomes of Polygonatum alte-lobatum, together with seven known compounds (2–8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, compounds 1, 3, 5, and 6 showed potent inhibition with IC50 values of 18.04 ± 2.14, 19.87 ± 2.70, 16.88 ± 1.35, and 18.50 ± 1.52 μM, respectively, against LPS-induced NO generation.
Original language | English |
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Pages (from-to) | 428-431 |
Number of pages | 4 |
Journal | Chemistry of Natural Compounds |
Volume | 60 |
Issue number | 3 |
DOIs | |
State | Published - May 2024 |
Keywords
- anti-inflammatory activity
- Asparagaceae
- homoisoflavonoid
- Polygonatumalte-lobatum
- rhizomes