A new angular naphthopyrone from feather star Comanthus parvicirrus (Müller, 1841)

Zong You Ke, Jun Wen Chen, Bo Yan Wu, Yi Yan Jhan, Zhi Hong Wen, Te An Kung, Ping Jyun Sung, Jih Jung Chen, Kuei Hung Lai, Hsu Ming Chung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A chemical investigation was carried out on a feather star Comanthus parvicirrus collected from the waters of Southern Taiwan, which led to the isolation of three angular naphthopyrones (1–3), including one new metabolite, 8‑hydroxy-5,6,9,10-tetramethoxy-2-methyl-4H-benzo[h]chromen-4-one (1). The structures of compounds 1–3 were assigned based on spectroscopic methods, including UV, MS, 1D- and 2D-NMR spectra, and the structure of 1 was established by single-crystal X-ray diffraction analysis directly. The compound 3 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.

Original languageEnglish
Article number132261
JournalJournal of Molecular Structure
Volume1253
DOIs
StatePublished - 5 Apr 2022

Keywords

  • Comanthus parvicirrus
  • Crinoid
  • Feather star
  • iNOS
  • Naphthopyrone
  • X-ray

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