A n + 1 strategy for macrocyclization based on free-radical carbonylation

Ilhyong Ryu*, Kiyoto Nagahara, Hiroshi Yamazaki, Shinji Tsunoi, Noboru Sonoda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The synthesis of 10-17 membered 4-oxolactones 2 from alkyl iodides 1 having an acryloxy moiety at the termini, carbon monoxide, and TTMSS (or tin hydride) takes place cleanly in moderate to good yield under free radical conditions. Low concentrations of 1 (0.005-0.01 M) are favorable for both intermolecular trap of CO and intramolecular acyl radical addition to the C-C double bond.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
JournalSynlett
Volume1994
Issue number8
DOIs
StatePublished - 1 Aug 1994

Fingerprint

Dive into the research topics of 'A n + 1 strategy for macrocyclization based on free-radical carbonylation'. Together they form a unique fingerprint.

Cite this