Abstract
(Figure Presented) A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic-resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.
Original language | English |
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Pages (from-to) | 655-661 |
Number of pages | 7 |
Journal | Advanced Materials |
Volume | 27 |
Issue number | 4 |
DOIs | |
State | Published - 27 Jan 2015 |
Keywords
- Brainâ-blood barrier
- Focused ultrasound
- Magnetic guidance
- Nanobubbles