A Molecularly Imprinted Polymer /Methylene Blue/Anodic Aluminum Oxide (MIP/MB/AAO) Nanocomposite Electrode for the Detection of Ultra-Low Concentration Troponin T in Urine

Chieh Chen, Yu Ting Cheng*, Hsiao En Tsai

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this paper, a molecularly imprinted polymer/methylene blue/anodic aluminum oxide (MIP/MB/AAO) nanocomposite sensing electrode is presented for direct detection of troponin T (cTnT) in urine for the first time. By combining the unique characteristics of the direct redox reaction of the MB in urine and the high surface area of the AAO template, the nanocomposite electrode can exhibit a low limit of detection (LoD) of 13.02 pg/ml and high sensitivity of 8.75 ×10-4 suitable for ultra-low concentration cTnT monitoring. Because the electrode has the advantages of cost-effective, rapid detection, direct and simple measurement, easy storage, etc., we believe it is adequate for the prediction of cardiac events via cTnT monitoring, thereby improving the quality of life of the patients requiring intensive care.

Original languageEnglish
Title of host publication2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2018-2021
Number of pages4
ISBN (Electronic)9784886864352
StatePublished - 2023
Event22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 - Kyoto, Japan
Duration: 25 Jun 202329 Jun 2023

Publication series

Name2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

Conference

Conference22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
Country/TerritoryJapan
CityKyoto
Period25/06/2329/06/23

Keywords

  • anodic aluminum oxide
  • cardiac troponin T
  • methylene blue
  • molecularly imprinted polymer
  • urine

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