A MOLECULAR IMPRINTED POLYMER (MIP)-BASED NT-PROBNP SENSING ELECTRODE USING LG9 PEPTIDES FOR HEART FAILURE MONITORING

Liang Kai Wang, Chih Hung Lin, Yu Ting Cheng*, Hsiao En Tsai, Chih Kuo Lee

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The abstract presents the first molecular imprinted polymer (MIP)-based N-terminal pro-B-type natriuretic peptide (NT-proBNP) sensing electrode using LG9 peptides as the template molecule for clinical study. The MIP-based sensing electrode is an electrochemical polymerized o-phenylenediamine (o-PD) film, which can accomplish the detection in 25 min., exhibit a sensitivity of 8.24x10-1 (ng/mL)-1 and the limit of detection (LoD) of 14.55 pg/ml in the concentration of NT-proBNP from 0.01 to 1.25 ng/ml. and be reused over than 6 times. As compared to other sensing techniques, the presented electrode exhibits excellent characteristics including high specificity and sensitivity, short testing time, and low cost suitable for ICU applications.

Original languageEnglish
Title of host publication2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022
EditorsReza Ghodssi, Jenna F. Chan
PublisherTransducer Research Foundation
Pages434-435
Number of pages2
ISBN (Electronic)9781940470047
StatePublished - 2022
Event2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022 - Hilton Head, United States
Duration: 5 Jun 20229 Jun 2022

Publication series

Name2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022

Conference

Conference2022 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2022
Country/TerritoryUnited States
CityHilton Head
Period5/06/229/06/22

Keywords

  • LG-9
  • Molecular Imprinted Polymer
  • NT-proBNP
  • serum test

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