A laser micromachined probe for recording multiple field potentials in the thalamus

You Yin Chen, Te Son Kuo, Fu Shan Jaw*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Multichannel recording provides integral information about electrical brain activities at one instant in time. In this study, multielectrode probes were fabricated to record the thalamic field potentials (FPs) responding to the electrical stimulation of nerve at the rat tail. At first, the number of sweeps used to form the evoked FP average and the spatial sampling density were determined by using cross-correlation functions, which were then statistically analyzed. The difference was significant at P<0.05, if the number of sweeps for averaging was more than 50 and the spatial interval between two consecutive recording sites was less than 50 μm in the anteroposterior, mediolateral and ventrodorsal directions. The responsive area was distributed vertically in the thalamus (ventral posterior lateral (VPL) nucleus); therefore, the recording sites were arranged in one linear array. Sixteen recording sites, which were 50 μm apart from each other, were distributed in the ventrodorsal direction. A 16-channel silicon probe was fabricated by using a standard photolithography process and laser micromachining techniques. The probe provides capabilities to record multiple thalamic evoked FPs and multiunit activities simultaneously.

Original languageEnglish
Pages (from-to)99-109
Number of pages11
JournalJournal of Neuroscience Methods
Issue number1
StatePublished - 15 Oct 2004


  • Cross-correlation
  • Field potential
  • Laser micromachining
  • Multielectrode probe
  • Thalamus


Dive into the research topics of 'A laser micromachined probe for recording multiple field potentials in the thalamus'. Together they form a unique fingerprint.

Cite this