TY - GEN
T1 - A Hybrid Voltage-Time Dual-Slope Capacitance-to-Digital Converter With Noise Shaping for Extracellular Vesicle Sensing Systems
AU - Hong, Bo Xun
AU - Tsai, Tsung Heng
N1 - Publisher Copyright:
© 2024 IEEE.
PY - 2024
Y1 - 2024
N2 - This paper presents a low-noise sensing system for early cancer detections, specifically targeting the biological protein microRNA within extracellular vesicles (EVs). The proposed sensing system integrates a CMOS MEMS transducer with a front-end readout circuit and utilizes a hybrid ADC for data conversion. The front-end readout circuit is designed to be less sensitive to parasitic capacitance, effectively suppressing interface noise. Additionally, the hybrid voltage-to-time ADC does not require an extra voltage-to-time converter (VTC) between the coarse and fine converters, thereby maintaining conversion linearity. Experimental results demonstrate a capacitance resolution of 10.3 fF and a microRNA-195 concentration detection range from 10 fM to 10 pM. The proposed EV sensing system achieves first-order noise shaping and reduces the required measurement time, with a FOM of 1.39 nJ/ conversion-step.
AB - This paper presents a low-noise sensing system for early cancer detections, specifically targeting the biological protein microRNA within extracellular vesicles (EVs). The proposed sensing system integrates a CMOS MEMS transducer with a front-end readout circuit and utilizes a hybrid ADC for data conversion. The front-end readout circuit is designed to be less sensitive to parasitic capacitance, effectively suppressing interface noise. Additionally, the hybrid voltage-to-time ADC does not require an extra voltage-to-time converter (VTC) between the coarse and fine converters, thereby maintaining conversion linearity. Experimental results demonstrate a capacitance resolution of 10.3 fF and a microRNA-195 concentration detection range from 10 fM to 10 pM. The proposed EV sensing system achieves first-order noise shaping and reduces the required measurement time, with a FOM of 1.39 nJ/ conversion-step.
KW - Analog-to-Digital
KW - Capacitive sensor
KW - CMOS MEMS
KW - Gold Interdigitated electrode
UR - http://www.scopus.com/inward/record.url?scp=85216096246&partnerID=8YFLogxK
U2 - 10.1109/APCCAS62602.2024.10808653
DO - 10.1109/APCCAS62602.2024.10808653
M3 - Conference contribution
AN - SCOPUS:85216096246
T3 - APCCAS and PrimeAsia 2024 - 2024 IEEE 20th Asia Pacific Conference on Circuits and Systems and IEEE Asia Pacific Conference on Postgraduate Research in Microelectronics Electronics, Proceeding
SP - 554
EP - 557
BT - APCCAS and PrimeAsia 2024 - 2024 IEEE 20th Asia Pacific Conference on Circuits and Systems and IEEE Asia Pacific Conference on Postgraduate Research in Microelectronics Electronics, Proceeding
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 20th IEEE Asia Pacific Conference on Circuits and Systems and IEEE Asia Pacific Conference on Postgraduate Research in Microelectronics Electronics, APCCAS and PrimeAsia 2024
Y2 - 7 November 2024 through 9 November 2024
ER -
