A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control

Wei Ming Chen; Her-Ming Chiueh; Tsan Jieh Chen; Chia Lun Ho; Chi Jeng; Shun Ting Chang; Ming-Dou Ker; Chun Yu Lin; Ya Chun Huang; Chia Wei Chou; Tsun Yuan Fan; Ming Seng Cheng; Sheng Fu Liang; Tzu Chieh Chien; Sih Yen Wu; Yu Lin Wang; Fu Zen Shaw; Yu Hsing Huang; Chia Hsiang Yang; Jin-Chern Chiou; Chih Wei Chang; Lei Chun Chou; Chung-Yu Wu

doi:10.1109/ISSCC.2013.6487737

A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control

Wei Ming Chen^*, Her-Ming Chiueh, Tsan Jieh Chen, Chia Lun Ho, Chi Jeng, Shun Ting Chang, Ming-Dou Ker, Chun Yu Lin, Ya Chun Huang, Chia Wei Chou, Tsun Yuan Fan, Ming Seng Cheng, Sheng Fu Liang, Tzu Chieh Chien, Sih Yen Wu, Yu Lin Wang, Fu Zen Shaw, Yu Hsing Huang, Chia Hsiang Yang, Jin-Chern ChiouChih Wei Chang, Lei Chun Chou, Chung-Yu Wu

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

49 Scopus citations

Abstract

Epilepsy is one of the most common neurological disorders. Around 1% of the world's population is affected, and nearly 25% of the patients cannot be treated by available therapies. Recently, seizure-triggered feedback electrical stimulation has been proved to effectively suppress pathological brain activities [1], but devices with accurate detection and effective stimulation for real-time seizure control are still unavailable. In this paper, a fully integrated 8-channel closed-loop seizure-control SoC with entropy-and-spectrum- aided seizure detection and adaptive neural stimulation is presented. This chip is powered wirelessly, aiming for implantable devices. The functionality of the fabricated chip is verified in animal tests.

Original language	English
Title of host publication	2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers
Pages	286-287
Number of pages	2
DOIs	https://doi.org/10.1109/ISSCC.2013.6487737
State	Published - 29 Apr 2013
Event	2013 60th IEEE International Solid-State Circuits Conference, ISSCC 2013 - San Francisco, CA, United States Duration: 17 Feb 2013 → 21 Feb 2013

Publication series

Name	Digest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume	56
ISSN (Print)	0193-6530

Conference

Conference	2013 60th IEEE International Solid-State Circuits Conference, ISSCC 2013
Country/Territory	United States
City	San Francisco, CA
Period	17/02/13 → 21/02/13

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10.1109/ISSCC.2013.6487737

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Chen, W. M., Chiueh, H-M., Chen, T. J., Ho, C. L., Jeng, C., Chang, S. T., Ker, M-D., Lin, C. Y., Huang, Y. C., Chou, C. W., Fan, T. Y., Cheng, M. S., Liang, S. F., Chien, T. C., Wu, S. Y., Wang, Y. L., Shaw, F. Z., Huang, Y. H., Yang, C. H., ... Wu, C-Y. (2013). A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control. In 2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers (pp. 286-287). [6487737] (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 56). https://doi.org/10.1109/ISSCC.2013.6487737

@inproceedings{1b878494d7cd4c0aa235ab11d8f68032,

title = "A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control",

abstract = "Epilepsy is one of the most common neurological disorders. Around 1% of the world's population is affected, and nearly 25% of the patients cannot be treated by available therapies. Recently, seizure-triggered feedback electrical stimulation has been proved to effectively suppress pathological brain activities [1], but devices with accurate detection and effective stimulation for real-time seizure control are still unavailable. In this paper, a fully integrated 8-channel closed-loop seizure-control SoC with entropy-and-spectrum- aided seizure detection and adaptive neural stimulation is presented. This chip is powered wirelessly, aiming for implantable devices. The functionality of the fabricated chip is verified in animal tests.",

author = "Chen, {Wei Ming} and Her-Ming Chiueh and Chen, {Tsan Jieh} and Ho, {Chia Lun} and Chi Jeng and Chang, {Shun Ting} and Ming-Dou Ker and Lin, {Chun Yu} and Huang, {Ya Chun} and Chou, {Chia Wei} and Fan, {Tsun Yuan} and Cheng, {Ming Seng} and Liang, {Sheng Fu} and Chien, {Tzu Chieh} and Wu, {Sih Yen} and Wang, {Yu Lin} and Shaw, {Fu Zen} and Huang, {Yu Hsing} and Yang, {Chia Hsiang} and Jin-Chern Chiou and Chang, {Chih Wei} and Chou, {Lei Chun} and Chung-Yu Wu",

year = "2013",

month = apr,

day = "29",

doi = "10.1109/ISSCC.2013.6487737",

language = "English",

isbn = "9781467345132",

series = "Digest of Technical Papers - IEEE International Solid-State Circuits Conference",

pages = "286--287",

booktitle = "2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers",

note = "2013 60th IEEE International Solid-State Circuits Conference, ISSCC 2013 ; Conference date: 17-02-2013 Through 21-02-2013",

}

Chen, WM, Chiueh, H-M, Chen, TJ, Ho, CL, Jeng, C, Chang, ST, Ker, M-D, Lin, CY, Huang, YC, Chou, CW, Fan, TY, Cheng, MS, Liang, SF, Chien, TC, Wu, SY, Wang, YL, Shaw, FZ, Huang, YH, Yang, CH, Chiou, J-C, Chang, CW, Chou, LC & Wu, C-Y 2013, A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control. in 2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers., 6487737, Digest of Technical Papers - IEEE International Solid-State Circuits Conference, vol. 56, pp. 286-287, 2013 60th IEEE International Solid-State Circuits Conference, ISSCC 2013, San Francisco, CA, United States, 17/02/13. https://doi.org/10.1109/ISSCC.2013.6487737

A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control. / Chen, Wei Ming; Chiueh, Her-Ming; Chen, Tsan Jieh et al.
2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers. 2013. p. 286-287 6487737 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 56).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control

AU - Chen, Wei Ming

AU - Chiueh, Her-Ming

AU - Chen, Tsan Jieh

AU - Ho, Chia Lun

AU - Jeng, Chi

AU - Chang, Shun Ting

AU - Ker, Ming-Dou

AU - Lin, Chun Yu

AU - Huang, Ya Chun

AU - Chou, Chia Wei

AU - Fan, Tsun Yuan

AU - Cheng, Ming Seng

AU - Liang, Sheng Fu

AU - Chien, Tzu Chieh

AU - Wu, Sih Yen

AU - Wang, Yu Lin

AU - Shaw, Fu Zen

AU - Huang, Yu Hsing

AU - Yang, Chia Hsiang

AU - Chiou, Jin-Chern

AU - Chang, Chih Wei

AU - Chou, Lei Chun

AU - Wu, Chung-Yu

PY - 2013/4/29

Y1 - 2013/4/29

N2 - Epilepsy is one of the most common neurological disorders. Around 1% of the world's population is affected, and nearly 25% of the patients cannot be treated by available therapies. Recently, seizure-triggered feedback electrical stimulation has been proved to effectively suppress pathological brain activities [1], but devices with accurate detection and effective stimulation for real-time seizure control are still unavailable. In this paper, a fully integrated 8-channel closed-loop seizure-control SoC with entropy-and-spectrum- aided seizure detection and adaptive neural stimulation is presented. This chip is powered wirelessly, aiming for implantable devices. The functionality of the fabricated chip is verified in animal tests.

AB - Epilepsy is one of the most common neurological disorders. Around 1% of the world's population is affected, and nearly 25% of the patients cannot be treated by available therapies. Recently, seizure-triggered feedback electrical stimulation has been proved to effectively suppress pathological brain activities [1], but devices with accurate detection and effective stimulation for real-time seizure control are still unavailable. In this paper, a fully integrated 8-channel closed-loop seizure-control SoC with entropy-and-spectrum- aided seizure detection and adaptive neural stimulation is presented. This chip is powered wirelessly, aiming for implantable devices. The functionality of the fabricated chip is verified in animal tests.

UR - http://www.scopus.com/inward/record.url?scp=84876547706&partnerID=8YFLogxK

U2 - 10.1109/ISSCC.2013.6487737

DO - 10.1109/ISSCC.2013.6487737

M3 - Conference contribution

AN - SCOPUS:84876547706

SN - 9781467345132

T3 - Digest of Technical Papers - IEEE International Solid-State Circuits Conference

SP - 286

EP - 287

BT - 2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers

T2 - 2013 60th IEEE International Solid-State Circuits Conference, ISSCC 2013

Y2 - 17 February 2013 through 21 February 2013

ER -

Chen WM, Chiueh H-M, Chen TJ, Ho CL, Jeng C, Chang ST et al. A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control. In 2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers. 2013. p. 286-287. 6487737. (Digest of Technical Papers - IEEE International Solid-State Circuits Conference). doi: 10.1109/ISSCC.2013.6487737

A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control

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