A fast digital chip implementing a real-time noise-resistant algorithm for estimating blood pressure using a non-invasive, cuffless PPG sensor

Jeremy H.S. Wang; Ming Hua Yeh; Paul C.-P. Chao; Tse Yi Tu; Yung Hua Kao; Rajeev Pandey

doi:10.1007/s00542-020-04946-y

A fast digital chip implementing a real-time noise-resistant algorithm for estimating blood pressure using a non-invasive, cuffless PPG sensor

Jeremy H.S. Wang, Ming Hua Yeh, Paul C.-P. Chao^*, Tse Yi Tu, Yung Hua Kao, Rajeev Pandey

^*Corresponding author for this work

Institute of Electrical and Control Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A fast digital chip is designed and fabricated successfully to implement the algorithm for estimating blood pressure (BP) in real time by a non-invasive cuffless photoplethysmogram (PPG) Sensor. The fast response accomplished by this digital computation chip is made possible by one-time calibration only and the Taiwan Semiconductor Manufacturing (TSMC) T18 process to realize the chip in an area of 3.97 mm². The experimental result shows that the overall power consumption of the chip is 15.62 mW. Finally, the blood pressure measurement platform has been developed with a user interface (UI) for long-term continuous cuffless BP measurement. The non-invasive blood pressure sensor is applied to the wrist arteries of 44 subjects for sensing the PPG pulsation of the blood vessel, and then estimating BPs (blood pressures). Measurement results shows that the maximum error in the BP measurement is ± 6 mmHg. Which is less than 8 mmHg, defined by the Advancement of Medical Instrumentation (AAMI) and British Hypertension Society (BHS) standard.

Original language	English
Pages (from-to)	3501–3516
Number of pages	16
Journal	Microsystem Technologies
Volume	26
Issue number	11
DOIs	https://doi.org/10.1007/s00542-020-04946-y
State	Published - 1 Nov 2020

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title = "A fast digital chip implementing a real-time noise-resistant algorithm for estimating blood pressure using a non-invasive, cuffless PPG sensor",

abstract = "A fast digital chip is designed and fabricated successfully to implement the algorithm for estimating blood pressure (BP) in real time by a non-invasive cuffless photoplethysmogram (PPG) Sensor. The fast response accomplished by this digital computation chip is made possible by one-time calibration only and the Taiwan Semiconductor Manufacturing (TSMC) T18 process to realize the chip in an area of 3.97 mm2. The experimental result shows that the overall power consumption of the chip is 15.62 mW. Finally, the blood pressure measurement platform has been developed with a user interface (UI) for long-term continuous cuffless BP measurement. The non-invasive blood pressure sensor is applied to the wrist arteries of 44 subjects for sensing the PPG pulsation of the blood vessel, and then estimating BPs (blood pressures). Measurement results shows that the maximum error in the BP measurement is ± 6 mmHg. Which is less than 8 mmHg, defined by the Advancement of Medical Instrumentation (AAMI) and British Hypertension Society (BHS) standard.",

author = "Wang, {Jeremy H.S.} and Yeh, {Ming Hua} and Chao, {Paul C.-P.} and Tu, {Tse Yi} and Kao, {Yung Hua} and Rajeev Pandey",

note = "Publisher Copyright: {\textcopyright} 2020, Springer-Verlag GmbH Germany, part of Springer Nature.",

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doi = "10.1007/s00542-020-04946-y",

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AU - Yeh, Ming Hua

AU - Chao, Paul C.-P.

AU - Tu, Tse Yi

AU - Kao, Yung Hua

AU - Pandey, Rajeev

PY - 2020/11/1

Y1 - 2020/11/1

N2 - A fast digital chip is designed and fabricated successfully to implement the algorithm for estimating blood pressure (BP) in real time by a non-invasive cuffless photoplethysmogram (PPG) Sensor. The fast response accomplished by this digital computation chip is made possible by one-time calibration only and the Taiwan Semiconductor Manufacturing (TSMC) T18 process to realize the chip in an area of 3.97 mm2. The experimental result shows that the overall power consumption of the chip is 15.62 mW. Finally, the blood pressure measurement platform has been developed with a user interface (UI) for long-term continuous cuffless BP measurement. The non-invasive blood pressure sensor is applied to the wrist arteries of 44 subjects for sensing the PPG pulsation of the blood vessel, and then estimating BPs (blood pressures). Measurement results shows that the maximum error in the BP measurement is ± 6 mmHg. Which is less than 8 mmHg, defined by the Advancement of Medical Instrumentation (AAMI) and British Hypertension Society (BHS) standard.

AB - A fast digital chip is designed and fabricated successfully to implement the algorithm for estimating blood pressure (BP) in real time by a non-invasive cuffless photoplethysmogram (PPG) Sensor. The fast response accomplished by this digital computation chip is made possible by one-time calibration only and the Taiwan Semiconductor Manufacturing (TSMC) T18 process to realize the chip in an area of 3.97 mm2. The experimental result shows that the overall power consumption of the chip is 15.62 mW. Finally, the blood pressure measurement platform has been developed with a user interface (UI) for long-term continuous cuffless BP measurement. The non-invasive blood pressure sensor is applied to the wrist arteries of 44 subjects for sensing the PPG pulsation of the blood vessel, and then estimating BPs (blood pressures). Measurement results shows that the maximum error in the BP measurement is ± 6 mmHg. Which is less than 8 mmHg, defined by the Advancement of Medical Instrumentation (AAMI) and British Hypertension Society (BHS) standard.

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A fast digital chip implementing a real-time noise-resistant algorithm for estimating blood pressure using a non-invasive, cuffless PPG sensor

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