Abstract
The screening of data sets for "positive data objects" is essential to modern technology. A (group) test that indicates whether a positive data object is in a specific subset or pool of the dataset can greatly facilitate the identification of all the positive data objects. A collection of tested pools is called a pooling design. Pooling designs are standard experimental tools in many biotechnical applications. In this paper, we use the (linear) subspace relation coupled with the general concept of a "containment matrix" to construct pooling designs with surprisingly high degrees of error correction (detection.) Error-correcting pooling designs are important to biotechnical applications where error rates often are as high as 15%. What is also surprising is that the rank of the pooling design containment matrix is independent of the number of positive data objects in the dataset.
Original language | English |
---|---|
Pages (from-to) | 1129-1136 |
Number of pages | 8 |
Journal | Journal of Computational Biology |
Volume | 12 |
Issue number | 8 |
DOIs | |
State | Published - Oct 2005 |
Keywords
- Error correction
- Pooling designs