Abstract
Described is a new synthetic route to bis(2-hydroxy-3,5-di-t-butylphenyl)methanone and its derivatives. The combined esterification/photo-Fries rearrangement approach enables a modular preparation of keto-bridged polyphenols. This protecting group-free process is highly atom- and step-economic, and a scalable production was easily achieved in the continuous-flow mode.
Original language | English |
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Article number | e202400269 |
Journal | Chemistry - An Asian Journal |
Volume | 19 |
Issue number | 13 |
DOIs | |
State | Published - 2 Jul 2024 |
Keywords
- hydroxybenzophenone
- oxygen donor ligand
- phenol
- photo-Fries rearrangement
- photoflow synthesis