A Concise Route to Keto-Bridged Polyphenols by Photo-Fries Rearrangement in Flow

Xin Jie Lin, Chien-Lung Wang, Chi How Peng*, Hsueh Ju Liu*, Yen Ku Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Described is a new synthetic route to bis(2-hydroxy-3,5-di-t-butylphenyl)methanone and its derivatives. The combined esterification/photo-Fries rearrangement approach enables a modular preparation of keto-bridged polyphenols. This protecting group-free process is highly atom- and step-economic, and a scalable production was easily achieved in the continuous-flow mode.

Original languageEnglish
Article numbere202400269
JournalChemistry - An Asian Journal
Volume19
Issue number13
DOIs
StatePublished - 2 Jul 2024

Keywords

  • hydroxybenzophenone
  • oxygen donor ligand
  • phenol
  • photo-Fries rearrangement
  • photoflow synthesis

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