A capillary-endothelium-mimetic microfluic chip for the study of chemotactic response

W. H. Wu, T. H. Punde*, P. C. Shih, C. Y. Fu, T. P. Wang, Long Hsu, H. Y. Chang, C. H. Liu

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We have developed a microsystem which mimics the dynamic, three dimensional micro environment in the blood vessel. The capillary-endothelium-mimetic microfluidic chip was used to study the chemotactic behavior of neutrophils by using quantitative approach. The quantitative study shows that at lower flow rates the chemotactic factor dominates over the flow rate increasing the exravasation of neutrophils whereas at higher flow rates the neutrophil extravasation minimizes.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1667-1669
Number of pages3
StatePublished - 1 Dec 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 3 Oct 20107 Oct 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume3

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Country/TerritoryNetherlands
CityGroningen
Period3/10/107/10/10

Keywords

  • Atherosclerosis
  • Biomimetics
  • Chemotaxis
  • Microfluidics
  • Neutrophil extravasation

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