A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsis severity

Chamindie Punyadeera*, E. Marion Schneider, Dave Schaffer, Hsin-Yun Hsu, Thomas O. Joos, Fabian Kriebel, Manfred Weiss, Wim F.J. Verhaegh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Introduction: In this study, we report on initial efforts to discover putative biomarkers for differential diagnosis of a systemic inflammatory response syndrome (SIRS) versus sepsis; and different stages of sepsis. In addition, we also investigated whether there are proteins that can discriminate between patients who survived sepsis from those who did not. Materials and Methods: Our study group consisted of 16 patients, of which 6 died and 10 survived. We daily measured 28 plasma proteins, for the whole stay of the patients in the ICU. Results: We observed that metalloproteinases and sE-selectin play a role in the distinction between SIRS and sepsis, and that IL-1, IP-10, sTNF-R2 and sFas appear to be indicative for the progression from sepsis to septic shock. A combined measurement of MMP-3, -10, IL-1, IP-10, sIL-2R, sFas, sTNF-R1, sRAGE, GM-CSF, IL-1 and Eotaxin allows for a good separation of patients that survived from those that died (mortality prediction with a sensitivity of 79% and specificity of 86%). Correlation analysis suggests a novel interaction between IL-1a and IP-10. Conclusion: The marker panel is ready to be verified in a validation study with or without therapeutic intervention.

Original languageEnglish
Pages (from-to)26-35
Number of pages10
JournalJournal of Emergencies, Trauma and Shock
Volume3
Issue number1
DOIs
StatePublished - 1 Jan 2010

Keywords

  • Biomarker
  • Cellular mechanism
  • SIRS
  • Sepsis outcome
  • Sepsis stage

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