A 460 800 Pixels CMOS Capacitive Sensor Array With Programmable Fusion Pixels and Noise Canceling for Life Science Applications

Lin Hung Lai*, Wen Yue Lin, Yu Wei Lu, Heng Yu Lui, Shinsuke Yoshida, Shih Hwa Chiou, Chen Yi Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Capacitive sensor array (CSA) plays an important role in life science applications, such as cell monitoring, DNA detection, or drug screening. This brief presents a 480×960 time-sharing TDC (ts-TDC) architecture of global shutter CSA. It provides an opportunity to merge interfacing, read-out and sampling circuits in pixel and dynamically adjust the electrode size according to the characteristic of biosample. Each pixel size is within 2.25× 2.25μ m2. The sensitivity of the proposed CSA is 6.896 codes/fF, and 43 fps can be adopted for real-time monitoring. Experiment results show that noise canceling significantly improves the sensing performance. Moreover, sensitivity can be optimized by given fusion-pixel pattern, making our proposal very flexible and suitable for cell biology applications and personalized medicine.

Original languageEnglish
Pages (from-to)1734-1738
Number of pages5
JournalIEEE Transactions on Circuits and Systems I: Regular Papers
Volume70
Issue number5
DOIs
StatePublished - 1 May 2023

Keywords

  • CMOS lab-on-chip
  • capacitance sensor array
  • fusion pixels
  • high throughput
  • ts-TDC

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