A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils

Tushar H. Punde; Wen Hao Wu; Po Chen Shih; Chien Yu Fu; Tsung Pao Wang; Long Hsu; Hawn You Chang; Cheng Hsien Liu

doi:10.1109/TRANSDUCERS.2011.5969361

A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils

Tushar H. Punde^*, Wen Hao Wu, Po Chen Shih, Chien Yu Fu, Tsung Pao Wang, Long Hsu, Hawn You Chang, Cheng Hsien Liu

^*Corresponding author for this work

Department of Electrophysics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Inflammation is a fundamental biology problem with daily threats to human health. In early inflammatory stage, the most important cell type involved is neutrophil, which represents the most massive leukocyte population. In this paper, we report a 3D reusable microfluidic chip which mimics the capillary endothelial lining and we have made an attempt to imitate the hemodynamic-factor in order to study the extravasation behavior of neutrophils. This microsystem is a continuous flow system which mimics the dynamic, three dimensional micro environment in the blood vessel.

Original language	English
Title of host publication	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Pages	2251-2254
Number of pages	4
DOIs	https://doi.org/10.1109/TRANSDUCERS.2011.5969361
State	Published - 2011
Event	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China Duration: 5 Jun 2011 → 9 Jun 2011

Publication series

Name	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

Conference

Conference	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Country/Territory	China
City	Beijing
Period	5/06/11 → 9/06/11

Keywords

Biomimetics
Chemotaxis
Microfluidics
Neutrophil extravasation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TRANSDUCERS.2011.5969361

Cite this

Punde, T. H., Wu, W. H., Shih, P. C., Fu, C. Y., Wang, T. P., Hsu, L., Chang, H. Y., & Liu, C. H. (2011). A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 (pp. 2251-2254). Article 5969361 (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11). https://doi.org/10.1109/TRANSDUCERS.2011.5969361

Punde, Tushar H. ; Wu, Wen Hao ; Shih, Po Chen et al. / A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils. 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. 2011. pp. 2251-2254 (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11).

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title = "A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils",

abstract = "Inflammation is a fundamental biology problem with daily threats to human health. In early inflammatory stage, the most important cell type involved is neutrophil, which represents the most massive leukocyte population. In this paper, we report a 3D reusable microfluidic chip which mimics the capillary endothelial lining and we have made an attempt to imitate the hemodynamic-factor in order to study the extravasation behavior of neutrophils. This microsystem is a continuous flow system which mimics the dynamic, three dimensional micro environment in the blood vessel.",

keywords = "Biomimetics, Chemotaxis, Microfluidics, Neutrophil extravasation",

author = "Punde, {Tushar H.} and Wu, {Wen Hao} and Shih, {Po Chen} and Fu, {Chien Yu} and Wang, {Tsung Pao} and Long Hsu and Chang, {Hawn You} and Liu, {Cheng Hsien}",

year = "2011",

doi = "10.1109/TRANSDUCERS.2011.5969361",

language = "English",

isbn = "9781457701573",

series = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11",

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booktitle = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11",

note = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 ; Conference date: 05-06-2011 Through 09-06-2011",

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Punde, TH, Wu, WH, Shih, PC, Fu, CY, Wang, TP, Hsu, L, Chang, HY & Liu, CH 2011, A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils. in 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11., 5969361, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, pp. 2251-2254, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, Beijing, China, 5/06/11. https://doi.org/10.1109/TRANSDUCERS.2011.5969361

A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils. / Punde, Tushar H.; Wu, Wen Hao; Shih, Po Chen et al.
2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. 2011. p. 2251-2254 5969361 (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils

AU - Punde, Tushar H.

AU - Wu, Wen Hao

AU - Shih, Po Chen

AU - Fu, Chien Yu

AU - Wang, Tsung Pao

AU - Hsu, Long

AU - Chang, Hawn You

AU - Liu, Cheng Hsien

PY - 2011

Y1 - 2011

N2 - Inflammation is a fundamental biology problem with daily threats to human health. In early inflammatory stage, the most important cell type involved is neutrophil, which represents the most massive leukocyte population. In this paper, we report a 3D reusable microfluidic chip which mimics the capillary endothelial lining and we have made an attempt to imitate the hemodynamic-factor in order to study the extravasation behavior of neutrophils. This microsystem is a continuous flow system which mimics the dynamic, three dimensional micro environment in the blood vessel.

AB - Inflammation is a fundamental biology problem with daily threats to human health. In early inflammatory stage, the most important cell type involved is neutrophil, which represents the most massive leukocyte population. In this paper, we report a 3D reusable microfluidic chip which mimics the capillary endothelial lining and we have made an attempt to imitate the hemodynamic-factor in order to study the extravasation behavior of neutrophils. This microsystem is a continuous flow system which mimics the dynamic, three dimensional micro environment in the blood vessel.

KW - Biomimetics

KW - Chemotaxis

KW - Microfluidics

KW - Neutrophil extravasation

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U2 - 10.1109/TRANSDUCERS.2011.5969361

DO - 10.1109/TRANSDUCERS.2011.5969361

M3 - Conference contribution

AN - SCOPUS:80052131601

SN - 9781457701573

T3 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

SP - 2251

EP - 2254

BT - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

T2 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

Y2 - 5 June 2011 through 9 June 2011

ER -

Punde TH, Wu WH, Shih PC, Fu CY, Wang TP, Hsu L et al. A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. 2011. p. 2251-2254. 5969361. (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11). doi: 10.1109/TRANSDUCERS.2011.5969361

A 3-D capillary-endothelium-mimetic microfluidic chip for studying the extravasation behaviour of neutrophils

Abstract

Publication series

Conference

Keywords

UN SDGs

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