A 2.56-μs Dynamic Range, 31.25-ps Resolution 2-D Vernier Digital-to-Time Converter (DTC) for Cell-Monitoring

Heng Yu Liu*, Lin Hung Lai, Wen Yue Lin, Yu Wei Lu, Yi Wei Lin, Chen Yi Lee

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Capacitive sensor array (CSA) has emerged as a prominent approach in the field of biomedical detection, particularly for the analysis of cell morphology and the construction of a Cell-on-CMOS platform. To enhance overall sensitivity, this paper presents a novel 2-D vernier digital-to-time converter (2D V-DTC) with a resolution of 31.25 ps and a dynamic range of 2.56 μs. The 2-D vernier structure attains sufficient resolution while reducing the number of delay elements required, and seamlessly integrates with a counter-based controller, extending the dynamic range to effectively cover a significantly larger sensing window. The CSA biochip, fabricated in 180-nm CMOS technology, achieves results with an overall sensitivity of 880 code/fF. This achievement translates into an sensing resolution of 1.13 aF, demonstrating its potential to further advance the development of CMOS-based cell-monitoring platform.

Original languageEnglish
Title of host publicationISCAS 2024 - IEEE International Symposium on Circuits and Systems
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9798350330991
DOIs
StatePublished - 2024
Event2024 IEEE International Symposium on Circuits and Systems, ISCAS 2024 - Singapore, Singapore
Duration: 19 May 202422 May 2024

Publication series

NameProceedings - IEEE International Symposium on Circuits and Systems
ISSN (Print)0271-4310

Conference

Conference2024 IEEE International Symposium on Circuits and Systems, ISCAS 2024
Country/TerritorySingapore
CitySingapore
Period19/05/2422/05/24

Keywords

  • 2-D Vernier
  • capacitive sensor array (CSA)
  • digital-to-time converter (DTC)
  • lab-on-a-chip (LOC)
  • ts-TDC

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