Following outpatient chemotherapy administration, cancer patients spend most of their time at home and this increases the risk of exposure of the patient's family members via the patient's excreta. The drugs can be detected in patients' body fluids (e.g., urine, emesis, and feces) as long as 48 to 72 hours following administration. As more and more chemotherapy is given in outpatient clinics and at home, it is extremely important for patients and caregivers to know the risks and hazards of potential exposure to these hazardous drugs (HDs). The content is composed by two parts: 1) guidelines for safe handling body fluids at home; 2) guidelines for safe handling chemotherapy at home. The guideline is intended for oncology nurses to use as a reference to develop patient education materials or to instruct patients and their families following safety measures to reduce exposure at home.