(+)-12-epi-fragilide G, a new chlorinated briarane from the sea whip gorgonian coral Junceella fragilis

Li Guo Zheng, Yu Chia Chang, Jih Jung Chen, Zhi Hong Wen*, Tsong Long Hwang, Ping Jyun Sung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Chemical investigation on the EtOAc-soluble fraction from the MeOH/DCM extract of a gorgonian coral Junceella fragilis afforded a new chlorinated briarane-type diterpenoid, (+)-12-epi-fragilide G (1) and this compound was found to be the enantiomer of (–)-12-epi-fragilide G (2). The structure of 1 was established on the basis of spectroscopic methods. Briarane 1 was found to inhibit the protein expression of pro-inflammatory iNOS in a murine macrophage-like cell line, RAW 264.7, stimulated with LPS and briarane 2 displayed inhibitory an effect on the generation of superoxide anion by human neutrophils.

Original languageEnglish
Pages (from-to)1601-1609
Number of pages9
JournalHeterocycles
Volume96
Issue number9
DOIs
StatePublished - 2018

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