Personal profile
Research Interests
Structural Biology, Structure based drug design, Nucleic acid binding proteins
Experience
2010/7~2013/7 Post-doctoral fellow, Institute of Molecular Biology, Academia Sinica
2013/8~present Assistant Professor, Institute of molecular medicine and bioengineering,
Department of Biological Science and Technology, NCTU
Education/Academic qualification
PhD, Bioinformatics and Structural Biology, National Tsing Hua University
External positions
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Collaborations and top research areas from the last five years
Projects
- 11 Finished
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闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(4/5)
Hsiao, Y.-Y. (PI)
1/02/22 → 31/01/23
Project: Government Ministry › Other Government Ministry Institute
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Optimization of the teaching and learning of biotechnology art course
Hsiao, Y.-Y. (PI)
1/08/21 → 31/07/22
Project: Government Ministry › Ministry of Education(Include School)
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闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(3/5)
Hsiao, Y.-Y. (PI)
1/02/21 → 31/01/22
Project: Government Ministry › Other Government Ministry Institute
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闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(2/5)
Hsiao, Y.-Y. (PI)
1/02/20 → 31/01/21
Project: Government Ministry › Other Government Ministry Institute
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闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(1/5)
Hsiao, Y.-Y. (PI)
1/02/19 → 30/04/20
Project: Government Ministry › Other Government Ministry Institute
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Disordered DNA-binding motif forms a modulation site for inhibiting the cancer immunotherapy target TREX
Huang, K. W., Yu Tsai, C., Wu, C. Y., Lin, W. C., Wu, M. T., Hsu, K. C., Yu Yang, C., Chang, I. Y., Liu, H. M., Chu, J. W. & Hsiao, Y. Y., 27 Jan 2026, In: Nucleic acids research. 54, 2, gkaf1511.Research output: Contribution to journal › Article › peer-review
Open Access -
ACTIVATABLE FUSION PROTEIN AND USE THEREOF
Tzou, S.-C. (Inventor), Hsiao, Y.-Y. (Inventor), 姜富耀 (Inventor), 張雁筑 (Inventor) & 周芊妤 (Inventor), 18 Jun 2024, Patent No. US12012442B2Research output: Patent
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Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids
Huang, K. W., Wu, C. Y., Toh, S. I., Liu, T. C., Tu, C. I., Lin, Y. H., Cheng, A. J., Kao, Y. T., Chu, J. W. & Hsiao, Y. Y., 27 Nov 2023, In: Nucleic acids research. 51, 21, p. 11927-11940 14 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
可活化融合蛋白質及其用途
Tzou, S.-C. (Inventor), Hsiao, Y.-Y. (Inventor), 姜富耀 (Inventor), 張雁筑 (Inventor) & 周芊妤 (Inventor), 1 Nov 2023, Patent No. I820386Research output: Patent
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APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
Liu, T. C., Lin, C. T., Chang, K. C., Guo, K. W., Wang, S., Chu, J.-W. & Hsiao, Y.-Y., 27 Jan 2021, In: Nature Communications. 12, 1, p. 1-12 12 p., 601.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations
Prizes
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Award for Outstanding Young postdoctoral researchers, Biophysical Society of R. O. C
Hsiao, Y.-Y. (Recipient), 2013
Prize: Honorary award
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Outstanding postdoctoral research award, National Science Council
Hsiao, Y.-Y. (Recipient), 2013
Prize: Honorary award