Projects per year
Personal profile
Research Interests
Structural Biology, Structure based drug design, Nucleic acid binding proteins
Experience
2010/7~2013/7 Post-doctoral fellow, Institute of Molecular Biology, Academia Sinica
2013/8~present Assistant Professor, Institute of molecular medicine and bioengineering,
Department of Biological Science and Technology, NCTU
Education/Academic qualification
PhD, Bioinformatics and Structural Biology, National Tsing Hua University
External positions
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Projects
- 11 Finished
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闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(4/5)
1/02/22 → 31/01/23
Project: Government Ministry › Other Government Ministry Institute
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Optimization of the teaching and learning of biotechnology art course
1/08/21 → 31/07/22
Project: Government Ministry › Ministry of Education(Include School)
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闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(3/5)
1/02/21 → 31/01/22
Project: Government Ministry › Other Government Ministry Institute
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闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(2/5)
1/02/20 → 31/01/21
Project: Government Ministry › Other Government Ministry Institute
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闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(1/5)
1/02/19 → 30/04/20
Project: Government Ministry › Other Government Ministry Institute
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APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
Liu, T. C., Lin, C. T., Chang, K. C., Guo, K. W., Wang, S., Chu, J-W. & Hsiao, Y-Y., 27 Jan 2021, In: Nature Communications. 12, 1, p. 1-12 12 p., 601.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites
Huang, K-W., Chen, J-W., Hua, T-Y., Chu, Y-Y., Chiu, T-Y., Liu, J-Y., Tu, C-I., Hsu, K. C., Kao, Y-T., Chu, J-W. & Hsiao, Y-Y., Dec 2021, In: Journal of the Chemical Society. 1, 2, p. 2315–2327 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Understanding APE1 cellular functions by the structural preference of exonuclease activities
Liu, T. C., Guo, K. W., Chu, J-W. & Hsiao, Y-Y., Jan 2021, In: Computational and Structural Biotechnology Journal. 19, p. 3682-3691 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity
Kang, C. Y., Huang, I. H., Chou, C. C., Wu, T. Y., Chang, J. C., Hsiao, Y. Y., Cheng, C. H., Tsai, W. J., Hsu, K. C. & Wang, S., 13 Mar 2020, In: Journal of Biological Chemistry. 295, 11, p. 3734-3745 12 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
MOLECULAR MECHANISMS OF TREX1 IN DNA REPAIR AND IMMUNE SILENCING
Huang, K-W., Liu, T-C. & Hsiao, Y-Y., 2019, In: Acta Crystallographica Section A: Foundations and Advances. 75, p. E101-E101 1 p.Research output: Contribution to journal › Meeting Abstract › peer-review
Prizes
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Award for Outstanding Young postdoctoral researchers, Biophysical Society of R. O. C
Hsiao, Yu-Yuan (Recipient), 2013
Prize: Honorary award
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Outstanding postdoctoral research award, National Science Council
Hsiao, Yu-Yuan (Recipient), 2013
Prize: Honorary award