Projects per year
Personal profile
Research Interests
Structural Biology, Structure based drug design, Nucleic acid binding proteins
Experience
2010/7~2013/7 Post-doctoral fellow, Institute of Molecular Biology, Academia Sinica
2013/8~present Assistant Professor, Institute of molecular medicine and bioengineering,
Department of Biological Science and Technology, NCTU
Education/Academic qualification
PhD, National Tsing Hua University
External positions
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Projects
- 8 Finished
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闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(2/5)
1/02/20 → 31/01/21
Project: Government Ministry › Ministry of Science and Technology
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闡明藥物研發的結構基礎: TREX1和HMGB2對免疫調節的綜合觀點(1/5)
1/02/19 → 30/04/20
Project: Government Ministry › Ministry of Science and Technology
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Structure, Function, and Biomedical Applications of APE1
1/08/18 → 30/04/19
Project: Government Ministry › Ministry of Science and Technology
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Molecular mechanisms and biomedical applications of TREX1 related cellular events
1/08/17 → 31/07/18
Project: Government Ministry › Ministry of Science and Technology
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Structural Analysis and Antiviral Inhibitor Development for DnaQ-family Exonucleases
1/08/16 → 31/07/17
Project: Government Ministry › Ministry of Science and Technology
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APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
Liu, T. C., Lin, C. T., Chang, K. C., Guo, K. W., Wang, S., Chu, J-W. & Hsiao, Y-Y., 27 Jan 2021, In: Nature Communications. 12, 1, 601.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity
Kang, C. Y., Huang, I. H., Chou, C. C., Wu, T. Y., Chang, J. C., Hsiao, Y. Y., Cheng, C. H., Tsai, W. J., Hsu, K. C. & Wang, S., 13 Mar 2020, In: Journal of Biological Chemistry. 295, 11, p. 3734-3745 12 p.Research output: Contribution to journal › Article › peer-review
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MOLECULAR MECHANISMS OF TREX1 IN DNA REPAIR AND IMMUNE SILENCING
Huang, K-W., Liu, T-C. & Hsiao, Y-Y., 2019, In: Acta Crystallographica Section A: Foundations and Advances. 75, p. E101-E101 1 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
Huang, K. W., Liu, T. C., Liang, R. Y., Chu, L. Y., Cheng, H. L., Chu, J-W. & Hsiao, Y-Y., 7 May 2018, In: PLoS Biology. 16, 5, 22 p., e2005653.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Structural insights into the duplex DNA processing of TREX2
Cheng, H. L., Lin, C. T., Huang, K. W., Wang, S., Lin, Y. T., Toh, S. I. & Hsiao, Y-Y., 1 Jan 2018, In: Nucleic acids research. 46, 22, p. 12166-12176 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Prizes
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Award for Outstanding Young postdoctoral researchers, Biophysical Society of R. O. C
Hsiao, Yu-Yuan (Recipient), 2013
Prize: Honorary award
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Outstanding postdoctoral research award, National Science Council
Hsiao, Yu-Yuan (Recipient), 2013
Prize: Honorary award