Human neurovascular disease, translational medical research model establishment, tumor brain metastasis, neurodevelopmental disorders and neurodegenerative diseases. We are good at using the important biomedical technology (cell molecular technology, optical imaging, clinical and basic technology, animal models) to study the possible mechanisms of neurovascular unit regulation in the development and degeneration of the central nervous system. And the dynamic regulation mechanisms of breast cancer brain metastases and chronic kidney disease- induced brain injury. we hope that we can understand the regulation mechanisms of neurovascular unit in human diseases with many directions to facilitate the therapeutic strategy and medical countermeasures in human disease.