Projects per year
Personal profile
Research Interests
Natural product chemistry, Enzyme chemistry, Structural biology
Experience
2011/09~2015/01 Postdoctoral Fellow, Genomics Research Center, Academia Sinica
2015/01~2018/03 Postdoctoral research associate, Department of Chemistry, The Scripps Research Institute
2018/04~2018/07 Researcher, Department of Bio-based Chemicals and Biocatalyst, Industrial Technology Research Institute
2018/8~ present Assistant Professor, Department of Biological Science and Technology, National Chiao Tung University
Education/Academic qualification
PhD, Biological Science and Technology, National Yang Ming Chiao Tung University
External positions
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Collaborations and top research areas from the last five years
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Projects
- 6 Finished
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Youssoufenes的生物合成研究與化學修飾，發展新型抗生素對抗多重抗藥性菌株
Chang, C.-Y. (PI)
1/08/23 → 31/07/24
Project: Government Ministry › Other Government Ministry Institute
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Youssoufenes的生物合成研究與化學修飾，發展新型抗生素對抗多重抗藥性菌株
Chang, C.-Y. (PI)
1/08/22 → 31/07/23
Project: Government Ministry › Other Government Ministry Institute
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Youssoufenes的生物合成研究與化學修飾，發展新型抗生素對抗多重抗藥性菌株
Chang, C.-Y. (PI)
1/08/21 → 31/07/22
Project: Government Ministry › Other Government Ministry Institute
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解析結核放線菌素之生合成途徑並利用改良酵素與化學修飾開發新一代抗TB、MRSA及VRE之抗生素
Chang, C.-Y. (PI)
1/12/20 → 31/07/21
Project: Government Ministry › Other Government Ministry Institute
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解析結核放線菌素之生合成途徑並利用改良酵素與化學修飾開發新一代抗TB、MRSA及VRE之抗生素
Chang, C.-Y. (PI)
1/12/19 → 31/07/20
Project: Government Ministry › Other Government Ministry Institute
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Crystal structure of CmnB involved in the biosynthesis of the nonproteinogenic amino acid l-2,3-diaminopropionic acid
Toh, S. I., Lo, C. L. & Chang, C. Y., 5 Jul 2023, In: Acta Crystallographica Section F:Structural Biology Communications. 79, p. 193-199 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin
Toh, S. I., Elaine Keisha, J., Wang, Y. L., Pan, Y. C., Jhu, Y. H., Hsiao, P. Y., Liao, W. T., Chen, P. Y., Ko, T. M. & Chang, C. Y., Dec 2023, In: Communications Biology. 6, 1, 1282.Research output: Contribution to journal › Article › peer-review
Open Access -
N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry
Wang, Y. L., Chang, C. Y., Hsu, N. S., Lo, I. W., Lin, K. H., Chen, C. L., Chang, C. F., Wang, Z. C., Ogasawara, Y., Dairi, T., Maruyama, C., Hamano, Y. & Li, T. L., Dec 2023, In: Nature Communications. 14, 1, 2528.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Biomimetic Total Synthesis of the Spiroindimicin Family of Natural Products
Zheng, X., Li, Y., Guan, M., Wang, L., Wei, S., Li, Y. C., Chang, C. Y. & Xu, Z., 2022, (Accepted/In press) In: Angewandte Chemie - International Edition.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Characterization and Structural Determination of CmnG-A, the Adenylation Domain That Activates the Nonproteinogenic Amino Acid Capreomycidine in Capreomycin Biosynthesis
Chen, I. H., Cheng, T., Wang, Y. L., Huang, S. J., Hsiao, Y. H., Lai, Y. T., Toh, S. I., Chu, J., Rudolf, J. D. & Chang, C. Y., 16 Dec 2022, In: ChemBioChem. 23, 24, e202200563.Research output: Contribution to journal › Article › peer-review
5 Scopus citations
Prizes
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Academic Publications Award, Ministry of Science and Technology
Chang, C.-Y. (Recipient), 2015
Prize: Honorary award