Personal profile
Research Interests
HIV-1 protease mediates virus maturation by processing viral structural protein Gag precursors during or after virus budding. The PR-mediated virus maturation is necessary for acquisition of viral infectivity. Timing of PR activation appears to be critical for virus assembly as premature PR activation can reduce virion release due to premature cleavage of Gag. Our primary goal is to elucidate the mechanism of PR activation. We also analyze the SARS-CoV structural domains involved in virus particle assembly. BST-2/tetherin has been reported to restrict enveloped virus release by tethering the progeny virions to the cell surface. We investigate the impact of BST-2/tetherin on coronavirus replication and explore whether coronaviruses or SARS-CoV has not yet identified strategy to oppose the BST-2/tetehrin anti-viral function.
Education/Academic qualification
PhD, Microbiology and Immunology, Oregon State University
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Collaborations and top research areas from the last five years
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A virus-like particle assembly system for probing the HIV-1 Gag–Pol dimerization domain: supporting evidence for reverse transcriptase involvement in protease activation by influencing Gag–Pol/Gag–Pol interaction
Hsieh, S. H., Huang, K. J. & Wang, C. T., Apr 2025, In: Journal of Virology. 99, 4Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Overcoming the challenges of scalable iPSC generation in translation medicine
Liu, D. H., Tseng, H. C., Lee, M. S., Chiou, G. Y., Wang, C. T., Lin, Y. Y., Lai, W. Y., Liu, Y. H., Wang, C. Y., Lee, C. Y., Kao, C. L., Chen, C. F. & Chien, Y., 1 Feb 2024, In: Journal of the Chinese Medical Association. 87, 2, p. 163-170 8 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
HIV-1 reverse transcriptase stability correlates with Gag cleavage efficiency: reverse transcriptase interaction implications for modulating protease activation
Hsieh, S. H., Yu, F. H., Huang, K. J. & Wang, C. T., Sep 2023, In: Journal of Virology. 97, 9Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
The role of negative pressure wound therapy in the treatment of poststernotomy mediastinitis in Asians: A single-center, retrospective cohort study
Wang, W. T., Lee, J. M., Chiang, K. J., Chiou, S. H., Wang, C. T. & Wu, S. H., Nov 2023, In: Health Science Reports. 6, 11, e1675.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Amino acid substitutions at the HIV-1 transframe region significantly impair virus infectivity
Yu, F. H., Huang, K. J. & Wang, C. T., Jan 2022, In: PLoS ONE. 17, 1 January, e0262477.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations