Center For Intelligent Drug Systems and Smart Bio-devices

2024

A hierarchical fusion strategy of deep learning networks for detection and segmentation of hepatocellular carcinoma from computed tomography images

Lee, I. C., Tsai, Y. P., Lin, Y. C., Chen, T. C., Yen, C. H., Chiu, N. C., Hwang, H. E., Liu, C. A., Huang, J. G., Lee, R. C., Chao, Y., Ho, S. Y. & Huang, Y. H., Dec 2024, In: Cancer Imaging. 24, 1, 43.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

An evolutionary learning-based method for identifying a circulating miRNA signature for breast cancer diagnosis prediction

Sathipati, S. Y., Tsai, M. J., Aimalla, N., Moat, L., Shukla, S. K., Allaire, P., Hebbring, S., Beheshti, A., Sharma, R. & Ho, S. Y., 1 Mar 2024, In: NAR Genomics and Bioinformatics. 6, 1, lqae022.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

A sensory signature of unaffected biological parents predicts the risk of autism in their offspring

Chen, C., Cheng, Y., Wu, C. T., Chiang, C. H., Wong, C. C., Huang, C. M., Martínez, R. M., Tzeng, O. J. L. & Fan, Y. T., Jan 2024, In: Psychiatry and Clinical Neurosciences. 78, 1, p. 60-68 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Associations of depression and perceived physical fatigability with white matter integrity in older adults

Lin, C., Yeh, F. C., Glynn, N. W., Gmelin, T., Wei, Y. C., Chen, Y. L., Huang, C. M., Shyu, Y. C. & Chen, C. K., Jun 2024, In: Psychiatry Research - Neuroimaging. 340, 111793.

Research output: Contribution to journal › Article › peer-review

Catalytic role of the enol ether intermediate in the intramolecular Stetter reaction: a computational perspective

Huang, G. T. & Yu, J. S. K., 26 Mar 2024, In: Physical Chemistry Chemical Physics. 26, 15, p. 11833-11853 21 p.

Research output: Contribution to journal › Article › peer-review

Chiral Luminophore Guided Self-Assembly of Achiral Block Copolymers for the Amplification of Circularly Polarized Luminescence

Shao, S. W., Puneet, P., Li, M. C., Ikai, T., Yashima, E. & Ho, R. M., 18 Jun 2024, In: ACS Macro Letters. 13, 6, p. 734-740 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Chiral Transfer of Linear Polysiloxane with Preferred-Handed Helical Conformation

Mure, T., Kinoshita, Y., Sakai, H., Morii, S., Wu, H. N., Yung, T. M., Yu, H. C., Nagashima, K., Higashiguchi, W., Ohta, N., Hayakawa, T., Nakamura, Y., Fujii, S., Li, M. C. & Hirai, T., 21 May 2024, In: ACS Macro Letters. 13, 5, p. 537-541 5 p.

Research output: Contribution to journal › Article › peer-review

Cognitive protection and brain entropy changes from omega-3 polyunsaturated fatty acids supplement in late-life depression: A 52-week randomized controlled trial

Lin, C., Lee, S.-H., Huang, C.-M., Wu, Y.-W., Chang, Y.-X., Liu, H.-L., Ng, S.-H., Cheng, Y.-C., Chiu, C.-C. & Wu, S.-C., Apr 2024, In: Journal of Affective Disorders. 351, p. 15-23 9 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Culture, prefrontal volume, and memory

Barber, N., Valoumas, I., Leger, K. R., Chang, Y. L., Huang, C. M., Goh, J. O. S. & Gutchess, A., Mar 2024, In: PLoS ONE. 19, 3 March, e0298235.

Research output: Contribution to journal › Article › peer-review

Open Access

Deciphering the Thermal Stability of Bacteriophage MS2-Derived Virus-like Particle and Its Engineered Variant

Vishwakarma, P., Puri, S., Banerjee, M., Chang, C. Y., Chang, C. C. & Chaudhuri, T. K., 12 Aug 2024, In: ACS Biomaterials Science and Engineering. 10, 8, p. 4812-4822 11 p.

Research output: Contribution to journal › Article › peer-review

De novo biosynthesis of 3-hydroxy-3-methylbutyrate as anti-catabolic supplement by metabolically engineered Escherichia coli

Huang, S. J., Lai, M. J., Chen, A. Y. & Lan, E. I., Jul 2024, In: Metabolic Engineering. 84, p. 48-58 11 p.

Research output: Contribution to journal › Article › peer-review

Developing a practical neurodevelopmental prediction model for targeting high-risk very preterm infants during visit after NICU: a retrospective national longitudinal cohort study

on behalf of the Taiwan Premature Infant Follow-up Network, Dec 2024, In: BMC Medicine. 22, 1, 68.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Development of an Adaptive Artifact Subspace Reconstruction Based on Hebbian/Anti-Hebbian Learning Networks for Enhancing BCI Performance

Tsai, B. Y., Diddi, S. V. S., Ko, L. W., Wang, S. J., Chang, C. Y. & Jung, T. P., 1 Jan 2024, In: IEEE Transactions on Neural Networks and Learning Systems. 35, 1, p. 348-361 14 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Development of rapid and efficient enterovirus typing and classification platform for real-time diagnostics

Chou, H. S., Wang, Y. L., Chang, C. Y., Fen Leo, B., Lin, Y. C., Reda Hussein, H., Kiew, L. V., Yang, J. Y. & Chang, C. C., 15 Aug 2024, In: Journal of Electroanalytical Chemistry. 967, 118479.

Research output: Contribution to journal › Article › peer-review

Dysregulation of the circRNA_0087207/miR-548c-3p/PLSR1-TGFB2 axis in Leber hereditary optic neuropathy in vitro

Yang, Y. P., Chang, Y. L., Chiou, G. Y., Lee, M. S., Wu, Y. R., Chen, P. W., Lin, Y. Y., Lai, W. Y., Liu, Y. H., Hwang, D. K. & Chien, Y., 1 Mar 2024, In: Journal of the Chinese Medical Association. 87, 3, p. 261-266 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Effect of C-type lectin 16 on dengue virus infection in Aedes aegypti salivary glands

Chang, Y. C., Liu, W. L., Fang, P. H., Li, J. C., Liu, K. L., Huang, J. L., Chen, H. W., Chen, C. H. & Kao, C. F., 1 May 2024, In: PNAS Nexus. 3, 5, pgae188.

Research output: Contribution to journal › Article › peer-review

Open Access

Europium Ion-Based Magnetic-Trapping and Fluorescence-Sensing Method for Detection of Pathogenic Bacteria

Jannatin, M., Yang, T. L., Su, Y. Y., Mai, R. T. & Chen, Y. C., 9 Apr 2024, In: Analytical chemistry. 96, 14, p. 5669-5676 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Expression of Weimberg xylose utilization pathway for succinate production by cyanobacteria under diurnal condition

Tsai, J. C., Lai, M. J. & Lan, E. I., Jul 2024, In: Journal of the Taiwan Institute of Chemical Engineers. 160, 105285.

Research output: Contribution to journal › Article › peer-review

Extracting Stress-Related EEG Patterns from Pre-Sleep EEG for Forecasting Slow-Wave Sleep Deficiency

Su, C. H., Ko, L. W., Jung, T. P., Onton, J., Tzou, S. C., Juang, J. C. & Hsu, C. Y., 2024, In: IEEE Transactions on Neural Systems and Rehabilitation Engineering. 32, p. 1817-1827 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Fabrication and application of glutathione biosensing SPCE strips with gold nanoparticle modification

Sun, Y. L., Chang, H. F., Chiang, P. H., Lin, M. W., Lin, C. H., Kuo, C. M., Lin, T. C., Lin, C. S. & Lin, C. S., 25 Jan 2024, In: RSC Advances. 14, 6, p. 3808-3819 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Functional neuroplasticity of facilitation and interference effects on inhibitory control following 3-month physical exercise in aging

Wu, H. Y., Huang, C. M., Hsu, A. L., Chen, C. N., Wu, C. W. & Chen, J. H., Feb 2024, In: Scientific reports. 14, 1, 3682.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Galectin-3 aggravates microglial activation and tau transmission in tauopathy

Siew, J. J., Chen, H. M., Chiu, F. L., Lee, C. W., Chang, Y. M., Chen, H. L., Nguyen, T. N. A., Liao, H. T., Liu, M., Hagar, H. T., Sun, Y. C., Lai, H. L., Kuo, M. H., Blum, D., Buée, L., Jin, L. W., Chen, S. Y., Ko, T. M., Huang, J. R. & Kuo, H. C. & 2 others, Liu, F. T. & Chern, Y., 16 Jan 2024, In: Journal of Clinical Investigation. 134, 2, e165523.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Immune-stealth VP28-conjugated heparin nanoparticles for enhanced and reversible anticoagulation

Hussein, H. R., Chang, C. Y., Zheng, Y., Yang, C. Y., Li, L. H., Lee, Y. T., Chen, J. Y., Liang, Y. C., Lin, C. J., Chang, Y. C., Geo, H. N., Noor, S. M., Kiew, L. V., Chen, F. R. & Chang, C. C., 22 Apr 2024, In: Nanotechnology. 35, 17, 175102.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

IoT-Based Strawberry Disease Detection With Wall-Mounted Monitoring Cameras

Lin, Y. B., Liu, C. Y., Chen, W. L., Chang, C. H., Ng, F. L., Yang, K. & Hsung, J., Jan 2024, In: IEEE Internet of Things Journal. 11, 1, p. 1439-1451 13 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Macular pigments produced from microalga Chlorella sp. and applied to alleviate the pathogenic process in diabetic mice

Lin, M. W., Chiu, W. H., Lin, C. H., Liu, D. H., Wu, P. C. & Lin, C. S., Mar 2024, In: Algal Research. 78, 103414.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Mechanistic and Kinetic Insights into Cellular Uptake of Biomimetic Dinitrosyl Iron Complexes and Intracellular Delivery of NO for Activation of Cytoprotective HO-1

Chiu, H., Chau Fang, A., Chen, Y. H., Koi, R. X., Yu, K. C., Hsieh, L. H., Shyu, Y. M., Amer, T. A. M., Hsueh, Y. J., Tsao, Y. T., Shen, Y. J., Wang, Y. M., Chen, H. C., Lu, Y. J., Huang, C. C. & Lu, T. T., 22 Apr 2024, In: JACS Au. 4, 4, p. 1550-1569 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Neutrophils Recruited by NKX2-1 Suppression via Activation of CXCLs/CXCR2 Axis Promote Lung Adenocarcinoma Progression

La'ah, A. S., Tsai, P. H., Yarmishyn, A. A., Ching, L. J., Chen, C. Y., Chien, Y., Chen, J. C. Y., Tsai, M. L., Chen, Y. C., Ma, C., Hsu, P. K., Luo, Y. H., Chen, Y. M., Chiou, G. Y., Lu, K. H., Lin, W. C., Chou, Y. T., Wang, M. L. & Chiou, S. H., 2024, (Accepted/In press) In: Advanced Science.

Research output: Contribution to journal › Article › peer-review

Open Access

Ophthalmic Tethered Gold Yarnball-Mediated Retained Drug Delivery for Eye Fundus Disease Treatment

Chou, S. J., Yang, Y. P., Chiang, M. R., Chen, C. Y., Lai, H. I. A. M., Lin, Y. Y., Wu, Y. R., Wang, I. C., Yarmishyn, A. A., Chiou, G. Y., Lin, T. C., Hwang, D. K., Chen, S. J., Chien, Y., Hu, S. H. & Chiou, S. H., Aug 2024, In: Small Science. 4, 8, 2400095.

Research output: Contribution to journal › Article › peer-review

Open Access

Origami-Inspired Conductive Paper-Based Folded Pressure Sensor with Interconnection Scaling at the Crease for Novel Wearable Applications

Karmakar, R. S., Huang, J. F., Chu, C. P., Mai, M. H., Chao, J. I., Liao, Y. C. & Lu, Y. W., 24 Jan 2024, In: ACS Applied Materials and Interfaces. 16, 3, p. 4231-4241 11 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Origami-Inspired Tactile Sensors Based On Electrical Contact Resistance (Ecr) For Wearable Applications

Karmakar, R. S., Huang, J. F., Chao, J. I., Liao, Y. C. & Lu, Y. W., 2024, IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024. Institute of Electrical and Electronics Engineers Inc., p. 829-832 4 p. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Overcoming the challenges of scalable iPSC generation in translation medicine

Liu, D. H., Tseng, H. C., Lee, M. S., Chiou, G. Y., Wang, C. T., Lin, Y. Y., Lai, W. Y., Liu, Y. H., Wang, C. Y., Lee, C. Y., Kao, C. L., Chen, C. F. & Chien, Y., 1 Feb 2024, In: Journal of the Chinese Medical Association. 87, 2, p. 163-170 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Paracrinal regulation of neutrophil functions by coronaviral infection in iPSC-derived alveolar type II epithelial cells

Chien, Y., Huang, X. Y., Yarmishyn, A. A., Chien, C. S., Liu, Y. H., Hsiao, Y. J., Lin, Y. Y., Lai, W. Y., Huang, S. C., Lee, M. S., Chiou, S. H., Yang, Y. P. & Chiou, G. Y., Jul 2024, In: Virus Research. 345, 199391.

Research output: Contribution to journal › Article › peer-review

Open Access

PDADMAC/Alginate-Coated Gold Nanorod For Eradication of Staphylococcus Aureus Biofilms

Manimaran, M., Teo, Y. Y., Kah, J. C. Y., Beishenaliev, A., Loke, Y. L., Foo, Y. Y., Ng, S. F., Chee, C. F., Chin, S. P., Faruqu, F. N., Chang, C. Y., Misran, M., Chung, L. Y., Leo, B. F., Chiou, S. H., Chang, C. C., Tay, S. T. & Kiew, L. V., 2024, In: International Journal of Nanomedicine. 19, p. 3697-3714 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Post-translational Modification of PD-1: Potential Targets for Cancer Immunotherapy

Lee, T. A., Tsai, E. Y., Liu, S. H., Hung, S. D. H., Chang, S. J., Chao, C. H., Lai, Y. J., Yamaguchi, H. & Li, C. W., 15 Mar 2024, In: Cancer Research. 84, 6, p. 800-807 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

Predicting suicidality in late-life depression by 3D convolutional neural network and cross-sample entropy analysis of resting-state fMRI

Lin, C., Huang, C.-M., Chang, W., Chang, Y.-X., Liu, H.-L., Ng, S.-H., Lin, H.-L., Lee, T.M.-C., Lee, S.-H. & Wu, S.-C., Jan 2024, In: Brain and Behavior. 14, 1, p. e3348

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Studying the Roles of the Renin–Angiotensin System in Accelerating the Disease of High-Fat-Diet-Induced Diabetic Nephropathy in a db/db and ACE2 Double-Gene-Knockout Mouse Model

Chen, C. Y., Lin, M. W., Xie, X. Y., Lin, C. H., Yang, C. W., Wu, P. C., Liu, D. H., Wu, C. J. & Lin, C. S., Jan 2024, In: International Journal Of Molecular Sciences. 25, 1, 329.

Research output: Contribution to journal › Article › peer-review

Open Access

Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases

Sun, X., Alfermann, J., Li, H., Watkins, M. B., Chen, Y. T., Morrell, T. E., Mayerthaler, F., Wang, C. Y., Komatsuzaki, T., Chu, J. W., Ando, N., Mootz, H. D. & Yang, H., Feb 2024, In: Nature Chemistry. 16, 2, p. 259-268 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Temporal Alpha Dissimilarity of ADHD Brain Network in Comparison With CPT and CATA

Lin, J. W., Fan, Z. C., Tzou, S. C., Wang, L. J. & Ko, L. W., 2024, In: IEEE Transactions on Neural Systems and Rehabilitation Engineering. 32, p. 1333-1343 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The non-mitotic role of HMMR in regulating the localization of TPX2 and the dynamics of microtubules in neurons

Chen, Y. J., Tseng, S. C., Chen, P. T. & Hwang, E., 2024, In: eLife. 13, RP94547.

Research output: Contribution to journal › Article › peer-review

Open Access

Time synchronization between parietal–frontocentral connectivity with MRCP and gait in post-stroke bipedal tasks

Phang, C. R., Su, K. H., Cheng, Y. Y., Chen, C. H. & Ko, L. W., Dec 2024, In: Journal of NeuroEngineering and Rehabilitation. 21, 1, 101.

Research output: Contribution to journal › Article › peer-review

Open Access

Trajectory Statistical Learning of the Potential Mean of Force and Diffusion Coefficient from Molecular Dynamics Simulations

Chen, Y. T., Yang, H. & Chu, J. W., 11 Jan 2024, In: Journal of Physical Chemistry B. 128, 1, p. 56-66 11 p.

Research output: Contribution to journal › Article › peer-review

2023

ACE2 and a Traditional Chinese Medicine Formula NRICM101 Could Alleviate the Inflammation and Pathogenic Process of Acute Lung Injury

Lin, C. H., Chen, Y. J., Lin, M. W., Chang, H. J., Yang, X. R. & Lin, C. S., Sep 2023, In: Medicina (Lithuania). 59, 9, 1554.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

A Fc-VEGF chimeric fusion enhances PD-L1 immunotherapy via inducing immune reprogramming and infiltration in the immunosuppressive tumor microenvironment

Kuo, C. L., Chou, H. Y., Lien, H. W., Yeh, C. A., Wang, J. R., Chen, C. H., Fan, C. C., Hsu, C. P., Kao, T. Y., Ko, T. M. & Lee, A. Y. L., Feb 2023, In: Cancer Immunology, Immunotherapy. 72, 2, p. 351-369 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

"A feeling of déjà vu": The Effects of Avatar Appearance-Similarity on Persuasiveness in Social Virtual Reality

Shih, M. T., Lee, Y. C., Huang, C. M. & Chan, L., 4 Oct 2023, In: Proceedings of the ACM on Human-Computer Interaction. 7, CSCW2, 3610167.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy

Chen, C. H., Weng, T. H., Huang, H. H., Huang, L. Y., Huang, K. Y., Chen, P. R., Yeh, K. Y., Huang, C. T., Chien, Y. T., Chuang, P. Y., Lin, Y. L., Tsai, N. M., Liu, S. J., Su, Y.-C., Weng, S. L. & Liao, K. W., Dec 2023, In: Journal of Experimental and Clinical Cancer Research. 42, 1, 29.

Research output: Contribution to journal › Article › peer-review

Open Access

A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations

Kao, P. Y., Chen, M. H., Chang, W. A., Pan, M. L., Shu, W. D., Jong, Y. J., Huang, H. D., Wang, C. Y., Chu, H. Y., Pan, C. T., Liu, Y. L. & Lin, Y. S., Feb 2023, In: PLoS ONE. 18, 2 February, e0281903.

Research output: Contribution to journal › Article › peer-review

Open Access

A lesion-selective albumin-CTLA4Ig as a safe and effective treatment for collagen-induced arthritis

Jiang, F. Y., Zhang, Y. Z., Tai, Y. H., Chou, C. Y., Hsieh, Y. C., Chang, Y. C., Huang, H. C., Li, Z. Q., Hsieh, Y. C., Chen, I. J., Huang, B. C., Su, Y. C., Lin, W. W., Lin, H. C., Chao, J. I., Yuan, S. S. F., Wang, Y. M., Cheng, T. L. & Tzou, S. C., Dec 2023, In: Inflammation and Regeneration. 43, 1, 13.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

A Low-Cost, Sensitive Reporter System Using Membrane-Tethered Horseradish Peroxidase for Efficient Gene Expression Analysis

Chang, M. S., Lee, C. Y., Liu, E. S., Chao, H., Wu, H. Y., Chang, Y. Y., Liu, Y. L., Chen, Y. T., Su, Y. C., Wang, Y. T., Cheng, T. L., Yen, C. H., Lin, C. W., Huang, H. K. & Lin, W. W., 26 Sep 2023, In: Analytical chemistry. 95, 38, p. 14341-14349 9 p.

Research output: Contribution to journal › Article › peer-review

A Low-Cost Fertilizer Medium Supplemented with Urea for the Lutein Production of Chlorella sp. and the Ability of the Lutein to Protect Cells against Blue Light Irradiation

Kuo, C. M., Yang, Y. C., Zhang, W. X., Wu, J. X., Chen, Y. T., Lin, C. H., Lin, M. W. & Lin, C. S., May 2023, In: Bioengineering. 10, 5, 594.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

An Exoskeleton BCI System for Stroke Rehabilitation Using Multi-modality Training Mode

Su, K. H., Chen, C. H., Chen, C. H., Zhang, Y. L. & Ko, L. W., 2023, 2023 International Automatic Control Conference, CACS 2023. Institute of Electrical and Electronics Engineers Inc., (2023 International Automatic Control Conference, CACS 2023).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Center For Intelligent Drug Systems and Smart Bio-devices

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